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Title: Biomimetic materials for protein storage and transport

Abstract

The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.

Inventors:
 [1];  [2]
  1. Elmhurst, IL
  2. Villa Park, IL
Issue Date:
Research Org.:
US Department of Energy (USDOE), Washington DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1044065
Patent Number(s):
8168746
Application Number:
12/148,518
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Firestone, Millicent A, and Laible, Philip D. Biomimetic materials for protein storage and transport. United States: N. p., 2012. Web.
Firestone, Millicent A, & Laible, Philip D. Biomimetic materials for protein storage and transport. United States.
Firestone, Millicent A, and Laible, Philip D. Tue . "Biomimetic materials for protein storage and transport". United States. https://www.osti.gov/servlets/purl/1044065.
@article{osti_1044065,
title = {Biomimetic materials for protein storage and transport},
author = {Firestone, Millicent A and Laible, Philip D},
abstractNote = {The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {5}
}

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Works referenced in this record:

Electron-Transfer Dynamics of Photosynthetic Reaction Centers in Thermoresponsive Soft Materials
journal, December 2005


Phospholipid Solubilization during Detergent Extraction of Rhodopsin from Photoreceptor Disk Membranes
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Comparison of M-Side Electron Transfer in Rb. sphaeroides and Rb. capsulatus Reaction Centers
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Magnetic Field-Induced Ordering of a Polymer-Grafted Biomembrane−Mimetic Hydrogel
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
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Structures of lipid–DNA complexes: supramolecular assembly and gene delivery
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The "Stealth" Liposome: A Prototypical Biomaterial
journal, December 1995