Biomimetic materials for protein storage and transport
Abstract
The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.
- Inventors:
-
- Elmhurst, IL
- Villa Park, IL
- Issue Date:
- Research Org.:
- US Department of Energy (USDOE), Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1044065
- Patent Number(s):
- 8168746
- Application Number:
- 12/148,518
- Assignee:
- UChicago Argonne, LLC (Chicago, IL)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- W-31-109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Firestone, Millicent A, and Laible, Philip D. Biomimetic materials for protein storage and transport. United States: N. p., 2012.
Web.
Firestone, Millicent A, & Laible, Philip D. Biomimetic materials for protein storage and transport. United States.
Firestone, Millicent A, and Laible, Philip D. Tue .
"Biomimetic materials for protein storage and transport". United States. https://www.osti.gov/servlets/purl/1044065.
@article{osti_1044065,
title = {Biomimetic materials for protein storage and transport},
author = {Firestone, Millicent A and Laible, Philip D},
abstractNote = {The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid comprising saturated phospholipids, lipopolymers, and a surfactant; cycling the mixture between a first temperature and a second temperature; maintaining the mixture as a solid for an indefinite period of time; diluting the mixture in detergent buffer so as to disrupt the composition of the mixture, and diluting to disrupt the fluid in its low viscosity state for removal of the guest molecules by, for example, dialysis, filtering or chromatography dialyzing/filtering the emulsified solid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 01 00:00:00 EDT 2012},
month = {Tue May 01 00:00:00 EDT 2012}
}
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Works referenced in this record:
Electron-Transfer Dynamics of Photosynthetic Reaction Centers in Thermoresponsive Soft Materials
journal, December 2005
- Laible, Philip D.; Kelley, Richard F.; Wasielewski, Michael R.
- The Journal of Physical Chemistry B, Vol. 109, Issue 49
Phospholipid Solubilization during Detergent Extraction of Rhodopsin from Photoreceptor Disk Membranes
journal, December 1995
- Aveldaño, Marta I.
- Archives of Biochemistry and Biophysics, Vol. 324, Issue 2
Comparison of M-Side Electron Transfer in Rb. sphaeroides and Rb. capsulatus Reaction Centers
journal, February 2002
- Kirmaier, Christine; Laible, Philip D.; Czarnecki, Kazimierz
- The Journal of Physical Chemistry B, Vol. 106, Issue 7
Magnetic Field-Induced Ordering of a Polymer-Grafted Biomembrane−Mimetic Hydrogel
journal, March 2000
- Firestone, Millicent A.; Tiede, David M.; Seifert, Sönke
- The Journal of Physical Chemistry B, Vol. 104, Issue 11
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
journal, September 1998
- Brünger, A. T.; Adams, P. D.; Clore, G. M.
- Acta Crystallographica Section D Biological Crystallography, Vol. 54, Issue 5
Structures of lipid–DNA complexes: supramolecular assembly and gene delivery
journal, August 2001
- Safinya, C.
- Current Opinion in Structural Biology, Vol. 11, Issue 4
The "Stealth" Liposome: A Prototypical Biomaterial
journal, December 1995
- Lasic, Danilo D.; Needham, David.
- Chemical Reviews, Vol. 95, Issue 8