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Title: Luminescent macrocyclic lanthanide complexes

Abstract

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

Inventors:
 [1];  [2];  [1]
  1. Berkeley, CA
  2. Campbell, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1043899
Patent Number(s):
8173800
Application Number:
11/839,509
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Raymond, Kenneth N, Corneillie, Todd M, and Xu, Jide. Luminescent macrocyclic lanthanide complexes. United States: N. p., 2012. Web.
Raymond, Kenneth N, Corneillie, Todd M, & Xu, Jide. Luminescent macrocyclic lanthanide complexes. United States.
Raymond, Kenneth N, Corneillie, Todd M, and Xu, Jide. Tue . "Luminescent macrocyclic lanthanide complexes". United States. https://www.osti.gov/servlets/purl/1043899.
@article{osti_1043899,
title = {Luminescent macrocyclic lanthanide complexes},
author = {Raymond, Kenneth N and Corneillie, Todd M and Xu, Jide},
abstractNote = {The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {5}
}

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