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Title: Low pressure electrospray ionization system and process for effective transmission of ions

Abstract

Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An "interfaceless" electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.

Inventors:
 [1];  [2];  [3];  [1]
  1. Richland, WA
  2. Kennewick, WA
  3. West Richland, WA
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1043897
Patent Number(s):
8173960
Application Number:
12/468,645
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions. United States: N. p., 2012. Web.
Tang, Keqi, Page, Jason S, Kelly, Ryan T, & Smith, Richard D. Low pressure electrospray ionization system and process for effective transmission of ions. United States.
Tang, Keqi, Page, Jason S, Kelly, Ryan T, and Smith, Richard D. Tue . "Low pressure electrospray ionization system and process for effective transmission of ions". United States. https://www.osti.gov/servlets/purl/1043897.
@article{osti_1043897,
title = {Low pressure electrospray ionization system and process for effective transmission of ions},
author = {Tang, Keqi and Page, Jason S and Kelly, Ryan T and Smith, Richard D},
abstractNote = {Systems and methods that provide up to complete transmission of ions between coupled stages with low effective ion losses. An "interfaceless" electrospray ionization system is further described that operates an electrospray at a reduced pressure such that standard electrospray sample solutions can be directly sprayed into an electrodynamic ion funnel which provides ion focusing and transmission of ions into a mass analyzer. Furthermore, chambers maintained at different pressures can allow for more optimal operating conditions for an electrospray emitter and an ion guide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {5}
}

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Works referenced in this record:

Ionization and transmission efficiency in an electrospray ionization—mass spectrometry interface
journal, September 2007


Energy distribution and spatial structure of electrosprays of ionic liquids in vacuo
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Charged droplet experiments
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Generation of Multiple Electrosprays Using Microfabricated Emitter Arrays for Improved Mass Spectrometric Sensitivity
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Electrohydrodynamic mass spectrometry
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Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface
journal, September 2006