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Title: Diagnosis and assessment of skeletal related disease using calcium 41

Abstract

A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope .sup.41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope .sup.41Ca by the patient, obtaining a sample of the radioactive calcium isotope .sup.41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.

Inventors:
 [1];  [2];  [3];  [4];  [4];  [5]
+ Show Inventor Affiliations
  1. Oakland, CA
  2. San Jose, CA
  3. Encinitas, CA
  4. Del Mar, CA
  5. San Diego, CA
Issue Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1042648
Patent Number(s):
8178076
Application Number:
11/283,034
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Hillegonds, Darren J, Vogel, John S, Fitzgerald, Robert L, Deftos, Leonard J, Herold, David, and Burton, Douglas W. Diagnosis and assessment of skeletal related disease using calcium 41. United States: N. p., 2012. Web.
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Hillegonds, Darren J, Vogel, John S, Fitzgerald, Robert L, Deftos, Leonard J, Herold, David, & Burton, Douglas W. Diagnosis and assessment of skeletal related disease using calcium 41. United States.
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Hillegonds, Darren J, Vogel, John S, Fitzgerald, Robert L, Deftos, Leonard J, Herold, David, and Burton, Douglas W. Tue . "Diagnosis and assessment of skeletal related disease using calcium 41". United States. https://www.osti.gov/servlets/purl/1042648.
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@article{osti_1042648,
title = {Diagnosis and assessment of skeletal related disease using calcium 41},
author = {Hillegonds, Darren J and Vogel, John S and Fitzgerald, Robert L and Deftos, Leonard J and Herold, David and Burton, Douglas W},
abstractNote = {A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope .sup.41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope .sup.41Ca by the patient, obtaining a sample of the radioactive calcium isotope .sup.41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 15 00:00:00 EDT 2012},
month = {Tue May 15 00:00:00 EDT 2012}
}
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Works referenced in this record:

Calcium-41 as a long-term biological tracer for bone resorption
journal, December 1990

  • Elmore, David; Bhattacharyya, Maryka H.; Sacco-Gibson, Nancy
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 52, Issue 3-4
  • https://doi.org/10.1016/0168-583X(90)90471-6

Protocol for assessing bone health in humans by tracing long-lived 41Ca isotope in urine, serum, and saliva samples
journal, September 2004

41Ca and Accelerator Mass Spectrometry to Monitor Calcium Metabolism in End Stage Renal Disease Patients
journal, November 2005

The study of skeletal calcium metabolism with 41Ca and 45Ca
journal, October 2000

  • Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(00)00341-4

Calcium metabolism in renal failure
journal, January 1975

Towards ultrahigh sensitivity analysis of 41Ca
journal, May 2003

Human calcium metabolism including bone resorption measured with 41Ca tracer
journal, March 1997

  • Freeman, Stewart P. H. T.; King, Janet C.; Vieira, Nancy E.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 123, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(96)00701-X

Calcium resorption from bone in a human studied by 41Ca tracing
journal, June 1994

Preparation of 41Ca AMS standards
journal, October 2000

  • Nishiizumi, Kunihiko; Caffee, Marc W.; DePaolo, Donald J.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(00)00150-6

Disturbance of Calcium Metabolism by Anticonvulsant Drugs
journal, October 1970

Biological sample preparation and 41Ca AMS measurement at LLNL
journal, May 1995

  • Freeman, S. P. H. T.; Serfass, R. E.; King, J. C.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 99, Issue 1-4
  • https://doi.org/10.1016/0168-583X(95)00342-8

Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology
journal, August 2004

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