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Title: Dual chain synthetic heparin-binding growth factor analogs

Abstract

The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

Inventors:
 [1];  [2];  [3]
  1. Gaithersburg, MD
  2. Poquott, NY
  3. Plainview, NY
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1040008
Patent Number(s):
8163717
Application Number:
12/574,484
Assignee:
BioSurface Engineering Technologies, Inc. (Rockville, MD)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Zamora, Paul O, Pena, Louis A, and Lin, Xinhua. Dual chain synthetic heparin-binding growth factor analogs. United States: N. p., 2012. Web.
Zamora, Paul O, Pena, Louis A, & Lin, Xinhua. Dual chain synthetic heparin-binding growth factor analogs. United States.
Zamora, Paul O, Pena, Louis A, and Lin, Xinhua. Tue . "Dual chain synthetic heparin-binding growth factor analogs". United States. https://www.osti.gov/servlets/purl/1040008.
@article{osti_1040008,
title = {Dual chain synthetic heparin-binding growth factor analogs},
author = {Zamora, Paul O and Pena, Louis A and Lin, Xinhua},
abstractNote = {The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {4}
}

Patent:

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