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Title: Detection of molecular interactions

Abstract

A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a condensed phase to a dispersed phase. An analyte to be tested is then added to the suspension. If the analyte binds to the ligand, a phase change occurs to indicate that the binding was successful.

Inventors:
 [1];  [2];  [3]
  1. Berkeley, CA
  2. Fremont, CA
  3. Brno, CH
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1036991
Patent Number(s):
8114602
Application Number:
10/581,371
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Groves, John T, Baksh, Michael M, and Jaros, Michal. Detection of molecular interactions. United States: N. p., 2012. Web.
Groves, John T, Baksh, Michael M, & Jaros, Michal. Detection of molecular interactions. United States.
Groves, John T, Baksh, Michael M, and Jaros, Michal. Tue . "Detection of molecular interactions". United States. https://www.osti.gov/servlets/purl/1036991.
@article{osti_1036991,
title = {Detection of molecular interactions},
author = {Groves, John T and Baksh, Michael M and Jaros, Michal},
abstractNote = {A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a condensed phase to a dispersed phase. An analyte to be tested is then added to the suspension. If the analyte binds to the ligand, a phase change occurs to indicate that the binding was successful.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {2}
}

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Works referenced in this record:

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