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Title: Nucleic acids, compositions and uses thereof

Abstract

The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.

Inventors:
 [1];  [2];  [2];  [2];  [3]
  1. (Micanopy, FL)
  2. Gainesville, FL
  3. Baltimore, MD
Issue Date:
Research Org.:
University of Florida Research Foundation, Inc. (Gainesville, FL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1036512
Patent Number(s):
8,119,367
Application Number:
12/256,155
Assignee:
University of Florida Research Foundation, Inc. (Gainesville, FL) GFO
DOE Contract Number:  
FC36-00GO10594; FC36-99GO10476
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Preston, III, James F., Chow, Virginia, Nong, Guang, Rice, John D, and John, Franz J. Nucleic acids, compositions and uses thereof. United States: N. p., 2012. Web.
Preston, III, James F., Chow, Virginia, Nong, Guang, Rice, John D, & John, Franz J. Nucleic acids, compositions and uses thereof. United States.
Preston, III, James F., Chow, Virginia, Nong, Guang, Rice, John D, and John, Franz J. Tue . "Nucleic acids, compositions and uses thereof". United States. https://www.osti.gov/servlets/purl/1036512.
@article{osti_1036512,
title = {Nucleic acids, compositions and uses thereof},
author = {Preston, III, James F. and Chow, Virginia and Nong, Guang and Rice, John D and John, Franz J},
abstractNote = {The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {2}
}

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