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Title: Recombinant microorganisms for increased production of organic acids

Abstract

Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

Inventors:
 [1];  [1];  [2]
  1. East Lansing, MI
  2. Holt, MI
Issue Date:
Research Org.:
Michigan Biotechnology Institute (Lansing, MI)
Sponsoring Org.:
USDOE
OSTI Identifier:
1036511
Patent Number(s):
8119377
Application Number:
11/722,579
Assignee:
Michigan Biotechnology Institute (Lansing, MI)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FC36-02GO12001
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States: N. p., 2012. Web.
Yi, Jian, Kleff, Susanne, & Guettler, Michael V. Recombinant microorganisms for increased production of organic acids. United States.
Yi, Jian, Kleff, Susanne, and Guettler, Michael V. Tue . "Recombinant microorganisms for increased production of organic acids". United States. https://www.osti.gov/servlets/purl/1036511.
@article{osti_1036511,
title = {Recombinant microorganisms for increased production of organic acids},
author = {Yi, Jian and Kleff, Susanne and Guettler, Michael V},
abstractNote = {Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {2}
}

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Works referenced in this record:

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z
journal, May 1997


Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen
journal, January 1999


Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant.
journal, January 1997


Biotechnology of succinic acid production and markets for derived industrial products
journal, May 1999