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Title: Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Inventors:
 [1];  [1];  [2];  [3];  [3];  [3];  [4];  [5];  [6]
  1. Durham, NC
  2. Los Alamos, NM
  3. Birmingham, AL
  4. Hoover, AL
  5. Alabaster, AL
  6. Chapel Hill, NC
Issue Date:
OSTI Identifier:
1034345
Assignee:
Duke University (Durham, NC); The Regents of the University of California (Oakland, CA); The University of Alabama at Birmingham Research Foundation (Birmingham, AL) LANL
Patent Number(s):
8,071,107
Application Number:
10/572,638
Contract Number:
AC52-06NA25396
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES