Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins
Abstract
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
- Inventors:
-
- Durham, NC
- Los Alamos, NM
- Birmingham, AL
- Hoover, AL
- Alabaster, AL
- Chapel Hill, NC
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1034345
- Patent Number(s):
- 8071107
- Application Number:
- 10/572,638
- Assignee:
- Duke University (Durham, NC); The Regents of the University of California (Oakland, CA); The University of Alabama at Birmingham Research Foundation (Birmingham, AL)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Haynes, Barton F, Gao, Feng, Korber, Bette T, Hahn, Beatrice H, Shaw, George M, Kothe, Denise, Li, Ying Ying, Decker, Julie, and Liao, Hua-Xin. Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins. United States: N. p., 2011.
Web.
Haynes, Barton F, Gao, Feng, Korber, Bette T, Hahn, Beatrice H, Shaw, George M, Kothe, Denise, Li, Ying Ying, Decker, Julie, & Liao, Hua-Xin. Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins. United States.
Haynes, Barton F, Gao, Feng, Korber, Bette T, Hahn, Beatrice H, Shaw, George M, Kothe, Denise, Li, Ying Ying, Decker, Julie, and Liao, Hua-Xin. Tue .
"Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins". United States. https://www.osti.gov/servlets/purl/1034345.
@article{osti_1034345,
title = {Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins},
author = {Haynes, Barton F and Gao, Feng and Korber, Bette T and Hahn, Beatrice H and Shaw, George M and Kothe, Denise and Li, Ying Ying and Decker, Julie and Liao, Hua-Xin},
abstractNote = {The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {12}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Bioorganic Approaches Towards HIV Vaccine Design
journal, August 2003
- Wang, Lai-Xi
- Current Pharmaceutical Design, Vol. 9, Issue 22
A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
journal, September 2006
- Liao, Hua-Xin; Sutherland, Laura L.; Xia, Shi-Mao
- Virology, Vol. 353, Issue 2, p. 268-282
Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002
- Gaschen, Brian; Taylor, Jesse; Yusim, Karina
- Science, Vol. 296, Issue 5577, p. 2354-2360
Consensus and Ancestral State HIV Vaccines
journal, March 2003
- Nickle, D. C.
- Science, Vol. 299, Issue 5612
Characterization and Selection of HIV-1 Subtype C Isolates for Use in Vaccine Development
journal, February 2003
- Williamson, Carolyn; Morris, Lynn; Maughan, Maureen F.
- AIDS Research and Human Retroviruses, Vol. 19, Issue 2, p. 133-144
Codon Usage Optimization of HIV Type 1 Subtype C gag , pol , env , and nef Genes: In Vitro Expression and Immune Responses in DNA-Vaccinated Mice
journal, September 2003
- Gao, Feng; Li, Yingying; Decker, Julie M.
- AIDS Research and Human Retroviruses, Vol. 19, Issue 9
Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity
journal, August 2004
- Gao, F.; Korber, B. T.; Weaver, Eric
- Expert Review of Vaccines, Vol. 3, Issue sup1
The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005
- Gallo, Robert C.
- The Lancet, Vol. 366, Issue 9500, p. 1894-1898
Toward an AIDS Vaccine
journal, May 2008
- Walker, Bruce D.; Burton, Dennis R.
- Science, Vol. 320, Issue 5877, p. 760-764
Generation of a Consensus Sequence from Prevalent and Incident HIV-1 Infections in West Africa to Guide AIDS Vaccine Development
journal, October 2002
- Ellenberger, Dennis L.; Li, Bin; Lupo, L. Davis
- Virology, Vol. 302, Issue 1
Multiple Effects of Codon Usage Optimization on Expression and Immunogenicity of DNA Candidate Vaccines Encoding the Human Immunodeficiency Virus Type 1 Gag Protein
journal, November 2001
- Deml, Ludwig; Bojak, Alexandra; Steck, Stephanie
- Journal of Virology, Vol. 75, Issue 22
Why Do We Not Yet Have a Human Immunodeficiency Virus Vaccine?
journal, October 2008
- Levine, Arnold J.
- Journal of Virology, Vol. 82, Issue 24
Human Immunodeficiency Virus Type 1 Subtype C Molecular Phylogeny: Consensus Sequence for an AIDS Vaccine Design?
journal, June 2002
- Novitsky, V.; Smith, U. R.; Gilbert, P.
- Journal of Virology, Vol. 76, Issue 11