skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Synthetic analogs of bacterial quorum sensors

Abstract

Bacterial quorum-sensing molecule analogs having the following structures: ##STR00001## and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.

Inventors:
 [1];  [1];  [1]
  1. Los Alamos, NM
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1034327
Patent Number(s):
8071790
Application Number:
12/551,994
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Iyer, Rashi, Ganguly, Kumkum, and Silks, Louis A. Synthetic analogs of bacterial quorum sensors. United States: N. p., 2011. Web.
Iyer, Rashi, Ganguly, Kumkum, & Silks, Louis A. Synthetic analogs of bacterial quorum sensors. United States.
Iyer, Rashi, Ganguly, Kumkum, and Silks, Louis A. Tue . "Synthetic analogs of bacterial quorum sensors". United States. https://www.osti.gov/servlets/purl/1034327.
@article{osti_1034327,
title = {Synthetic analogs of bacterial quorum sensors},
author = {Iyer, Rashi and Ganguly, Kumkum and Silks, Louis A},
abstractNote = {Bacterial quorum-sensing molecule analogs having the following structures: ##STR00001## and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {12}
}

Patent:

Save / Share:

Works referenced in this record:

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
journal, January 2002


Roles of Pseudomonas aeruginosa las andrhl Quorum-Sensing Systems in Control of Twitching Motility
journal, March 1999


The Synthesis of Optically Pure Enantiomers of N -Acyl-homoserine Lactone Autoinducers and Their Analogues
journal, April 2001


Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides
journal, March 2007


Quorum-Sensing Genes in Pseudomonas aeruginosa Biofilms: Their Role and Expression Patterns
journal, April 2001


DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
journal, January 1990