Anti-influenza M2e antibody
Abstract
Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.
- Inventors:
-
- Santa Fe, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1034171
- Patent Number(s):
- 8080244
- Application Number:
- 12/592,241
- Assignee:
- Los Alamos National Security, LLC (Los Alamos, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Bradbury, Andrew M. Anti-influenza M2e antibody. United States: N. p., 2011.
Web.
Bradbury, Andrew M. Anti-influenza M2e antibody. United States.
Bradbury, Andrew M. Tue .
"Anti-influenza M2e antibody". United States. https://www.osti.gov/servlets/purl/1034171.
@article{osti_1034171,
title = {Anti-influenza M2e antibody},
author = {Bradbury, Andrew M},
abstractNote = {Humanized recombinant and monoclonal antibodies specific for the ectodomain of the influenza virus M2 ion channel protein are disclosed. The antibodies of the invention have anti-viral activity and may be useful as anti-viral therapeutics and/or prophylactic/vaccine agents for inhibiting influenza virus replication and for treating individuals infected with influenza.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {12}
}
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Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus☆
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Effects of humanization by variable domain resurfacing on the antiviral activity of a single-chain antibody against respiratory syncytial virus
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- Delagrave, Simon; Catalan, John; Sweet, Charles
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