Id-1 and Id-2 genes and products as markers of epithelial cancer

Desprez, Pierre-Yves; Campisi, Judith

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Title: Id-1 and Id-2 genes and products as markers of epithelial cancer

Abstract

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Inventors:

Desprez, Pierre-Yves ^[1]; Campisi, Judith ^[2]

El Cerrito, CA
Berkeley, CA

Issue Date:: 2011-10-04

Research Org.:: Univ. of California (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1029286

Patent Number(s):: 8030012

Application Number:: 11/390,682

Assignee:: OAK

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
C12Q1/6886 - for cancer
C12Q2600/106 - Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q2600/156 - Polymorphic or mutational markers
C12Q2600/158 - Expression markers

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/57407 - {Specifically defined cancers}
G01N33/57415 - {of breast}
G01N33/5743 - {of skin, e.g. melanoma}
G01N33/57434 - {of prostate}
G01N33/57492 - {involving compounds localized on the membrane of tumor or cancer cells}

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DOE Contract Number:: AC03-76SF00098; AC02-05CH11231

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Desprez, Pierre-Yves, and Campisi, Judith. Id-1 and Id-2 genes and products as markers of epithelial cancer.  United States: N. p., 2011. 
        Web.

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                    Desprez, Pierre-Yves, & Campisi, Judith. Id-1 and Id-2 genes and products as markers of epithelial cancer.  United States.

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                    Desprez, Pierre-Yves, and Campisi, Judith. Tue .  
        "Id-1 and Id-2 genes and products as markers of epithelial cancer".  United States.  https://www.osti.gov/servlets/purl/1029286.

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@article{osti_1029286,

  title        = {Id-1 and Id-2 genes and products as markers of epithelial cancer},

  author       = {Desprez, Pierre-Yves and Campisi, Judith},

  abstractNote = {A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {10}

}

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Works referenced in this record:

Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression
journal, March 2004

Coppe, Jean-Philippe; Itahana, Yoko; Moore, Dan H.
Clinical Cancer Research, Vol. 10, Issue 6
https://doi.org/10.1158/1078-0432.CCR-03-0933

Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer
journal, March 2003

Schoppmann, Sebastian F.; Schindl, Monika; Bayer, Guenther
International Journal of Cancer, Vol. 104, Issue 6
https://doi.org/10.1002/ijc.11009

The Id proteins: targets for inhibiting tumor cells and their blood supply
journal, October 2001

Benezra, Robert
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1551, Issue 2
https://doi.org/10.1016/S0304-419X(01)00028-2

Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions
journal, October 1997

van Dekken, H.; Rosenberg, Carla; Krijtenburg, Pieter J.
Histochemistry and Cell Biology, Vol. 108, Issue 4-5
https://doi.org/10.1007/s004180050182

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
journal, October 2003

Fong, S.; Itahana, Y.; Sumida, T.
Proceedings of the National Academy of Sciences, Vol. 100, Issue 23
https://doi.org/10.1073/pnas.2230238100

Over Expression of ID-1 in Prostate Cancer
journal, June 2002

Ouyang, X. S.; Wang, X.; Lee, D. T. W.
Journal of Urology, Vol. 167, Issue 6
https://doi.org/10.1016/S0022-5347(05)65044-6

Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma
journal, September 2005

Straume, O.; Akslen, L. A.
British Journal of Cancer, Vol. 93, Issue 8
https://doi.org/10.1038/sj.bjc.6602792

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
journal, April 2001

Takai, Noriyuki; Miyazaki, Tami; Fujisawa, Kayo
Cancer Letters, Vol. 165, Issue 2
https://doi.org/10.1016/S0304-3835(01)00433-5

Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat
journal, June 2001

Ouyang, X. S.
Carcinogenesis, Vol. 22, Issue 6
https://doi.org/10.1093/carcin/22.6.965

Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages
journal, June 1999

Morrow, Maureen A.; Mayer, Elizabeth W.; Perez, Cesar A.
Molecular Immunology, Vol. 36, Issue 8
https://doi.org/10.1016/S0161-5890(99)00071-1

Gene expression profiling predicts clinical outcome of prostate cancer
journal, March 2004

Glinsky, Gennadi V.; Glinskii, Anna B.; Stephenson, Andrew J.
Journal of Clinical Investigation, Vol. 113, Issue 6
https://doi.org/10.1172/JCI20032

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value
journal, January 2003

Vandesompele, Jo; Edsjö, Anders; De Preter, Katleen
Oncogene, Vol. 22, Issue 3
https://doi.org/10.1038/sj.onc.1206148

Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.
journal, June 1995

Desprez, P. Y.; Hara, E.; Bissell, M. J.
Molecular and Cellular Biology, Vol. 15, Issue 6
https://doi.org/10.1128/MCB.15.6.3398

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
journal, November 2007

Yuen, H-F; Chan, Y-P; Chan, K-K
British Journal of Cancer, Vol. 97, Issue 10
https://doi.org/10.1038/sj.bjc.6604035

Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents
journal, May 1999

Liu, Yong; Thor, Ann; Shtivelman, Emma
Journal of Biological Chemistry, Vol. 274, Issue 19
https://doi.org/10.1074/jbc.274.19.13338

Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis
journal, September 1999

Maruyama, Haruhisa; Kleeff, Jörg; Wildi, Stefan
The American Journal of Pathology, Vol. 155, Issue 3, p. 815-822
https://doi.org/10.1016/S0002-9440(10)65180-2

Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer
journal, September 2007

Forootan, Shiva S.; Wong, Yong-Chuan; Dodson, Andrew
Human Pathology, Vol. 38, Issue 9
https://doi.org/10.1016/j.humpath.2007.02.011

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Id-1 and Id-2 genes and products as markers of epithelial cancer

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A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.
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Similar Records

Title: Id-1 and Id-2 genes and products as markers of epithelial cancer

Abstract

Citation Formats

Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression journal, March 2004

Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer journal, March 2003

The Id proteins: targets for inhibiting tumor cells and their blood supply journal, October 2001

Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions journal, October 1997

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis journal, October 2003

Over Expression of ID-1 in Prostate Cancer journal, June 2002

Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma journal, September 2005

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma journal, April 2001

Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat journal, June 2001

Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages journal, June 1999

Gene expression profiling predicts clinical outcome of prostate cancer journal, March 2004

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value journal, January 2003

Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. journal, June 1995

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma journal, November 2007

Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents journal, May 1999

Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis journal, September 1999

Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer journal, September 2007

Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression
journal, March 2004

Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer
journal, March 2003

The Id proteins: targets for inhibiting tumor cells and their blood supply
journal, October 2001

Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions
journal, October 1997

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
journal, October 2003

Over Expression of ID-1 in Prostate Cancer
journal, June 2002

Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma
journal, September 2005

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
journal, April 2001

Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat
journal, June 2001

Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages
journal, June 1999

Gene expression profiling predicts clinical outcome of prostate cancer
journal, March 2004

ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value
journal, January 2003

Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.
journal, June 1995

Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
journal, November 2007

Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents
journal, May 1999

Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis
journal, September 1999

Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer
journal, September 2007