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Title: Id-1 and Id-2 genes and products as markers of epithelial cancer

Abstract

A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.

Inventors:
 [1];  [2]
  1. El Cerrito, CA
  2. Berkeley, CA
Issue Date:
Research Org.:
Univ. of California (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1029286
Patent Number(s):
8030012
Application Number:
11/390,682
Assignee:
OAK
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC03-76SF00098; AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Desprez, Pierre-Yves, and Campisi, Judith. Id-1 and Id-2 genes and products as markers of epithelial cancer. United States: N. p., 2011. Web.
Desprez, Pierre-Yves, & Campisi, Judith. Id-1 and Id-2 genes and products as markers of epithelial cancer. United States.
Desprez, Pierre-Yves, and Campisi, Judith. Tue . "Id-1 and Id-2 genes and products as markers of epithelial cancer". United States. https://www.osti.gov/servlets/purl/1029286.
@article{osti_1029286,
title = {Id-1 and Id-2 genes and products as markers of epithelial cancer},
author = {Desprez, Pierre-Yves and Campisi, Judith},
abstractNote = {A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {10}
}

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Works referenced in this record:

Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression
journal, March 2004


Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer
journal, March 2003


The Id proteins: targets for inhibiting tumor cells and their blood supply
journal, October 2001


Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions
journal, October 1997


Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
journal, October 2003


Over Expression of ID-1 in Prostate Cancer
journal, June 2002


Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma
journal, April 2001


Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages
journal, June 1999


Gene expression profiling predicts clinical outcome of prostate cancer
journal, March 2004


ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value
journal, January 2003


Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.
journal, June 1995


Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
journal, November 2007


Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents
journal, May 1999


Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis
journal, September 1999


Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer
journal, September 2007