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Title: Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production

Abstract

The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.

Inventors:
 [1];  [2];  [3];  [4]
  1. Chanhassen, MN
  2. Eden Prairie, MN
  3. Apple Valley, MN
  4. Plymouth, MN
Issue Date:
Research Org.:
Cargill, Incorporated (Wayzata, MN)
Sponsoring Org.:
USDOE
OSTI Identifier:
1029284
Patent Number(s):
8030045
Application Number:
12/310,503
Assignee:
Cargill, Incorporated (Wayzata, MN)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
DOE Contract Number:  
GO 13144
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Jessen, Holly Jean, Liao, Hans H, Gort, Steven John, and Selifonova, Olga V. Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production. United States: N. p., 2011. Web.
Jessen, Holly Jean, Liao, Hans H, Gort, Steven John, & Selifonova, Olga V. Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production. United States.
Jessen, Holly Jean, Liao, Hans H, Gort, Steven John, and Selifonova, Olga V. Tue . "Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production". United States. https://www.osti.gov/servlets/purl/1029284.
@article{osti_1029284,
title = {Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production},
author = {Jessen, Holly Jean and Liao, Hans H and Gort, Steven John and Selifonova, Olga V},
abstractNote = {The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {10}
}

Patent:

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Works referenced in this record:

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