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Title: Simple, rapid method for the preparation of isotopically labeled formaldehyde

Abstract

Isotopically labeled formaldehyde (*C.sup..sctn.H.sub.2O) is prepared from labeled methyl iodide (*C.sup..sctn.H.sub.3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C.sup..sctn.H.sub.2O with little or no *C isotopic dilution. The simple, efficient production of .sup.11CH.sub.2O is described. The use of the .sup.11CH.sub.2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.

Inventors:
 [1];  [2];  [3];  [4]
  1. Port Jefferson, NY
  2. Mains, DE
  3. Aabergen, DE
  4. Bellport, NY
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1029276
Patent Number(s):
8030526
Application Number:
12/488,680
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Hooker, Jacob Matthew, Schonberger, Matthias, Schieferstein, Hanno, and Fowler, Joanna S. Simple, rapid method for the preparation of isotopically labeled formaldehyde. United States: N. p., 2011. Web.
Hooker, Jacob Matthew, Schonberger, Matthias, Schieferstein, Hanno, & Fowler, Joanna S. Simple, rapid method for the preparation of isotopically labeled formaldehyde. United States.
Hooker, Jacob Matthew, Schonberger, Matthias, Schieferstein, Hanno, and Fowler, Joanna S. Tue . "Simple, rapid method for the preparation of isotopically labeled formaldehyde". United States. https://www.osti.gov/servlets/purl/1029276.
@article{osti_1029276,
title = {Simple, rapid method for the preparation of isotopically labeled formaldehyde},
author = {Hooker, Jacob Matthew and Schonberger, Matthias and Schieferstein, Hanno and Fowler, Joanna S},
abstractNote = {Isotopically labeled formaldehyde (*C.sup..sctn.H.sub.2O) is prepared from labeled methyl iodide (*C.sup..sctn.H.sub.3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C.sup..sctn.H.sub.2O with little or no *C isotopic dilution. The simple, efficient production of .sup.11CH.sub.2O is described. The use of the .sup.11CH.sub.2O for the formation of positron emission tomography tracer compounds is described. The reaction can be incorporated into automated equipment available to radiochemistry laboratories. The isotopically labeled formaldehyde can be used in a variety of reactions to provide radiotracer compounds for imaging studies as well as for scintillation counting and autoradiography.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {10}
}

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Works referenced in this record:

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journal, November 2008


A Simple, Rapid Method for the Preparation of [ 11 C]Formaldehyde
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Automated synthesis of 11C-labelled radiopharmaceuticals: Imipramine, chlorpromazine, nicotine and methionine
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