Synthetic peptides that cause F-actin bundling and block actin depolymerization
Abstract
Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.
- Inventors:
-
- Raleigh, NC
- Savoy, IL
- Berkeley, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1028779
- Patent Number(s):
- 8039438
- Application Number:
- 10/576,757
- Assignee:
- The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098; AI01-91ER20031
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Sederoff, Heike, Huber, Steven C, and Larabell, Carolyn A. Synthetic peptides that cause F-actin bundling and block actin depolymerization. United States: N. p., 2011.
Web.
Sederoff, Heike, Huber, Steven C, & Larabell, Carolyn A. Synthetic peptides that cause F-actin bundling and block actin depolymerization. United States.
Sederoff, Heike, Huber, Steven C, and Larabell, Carolyn A. Tue .
"Synthetic peptides that cause F-actin bundling and block actin depolymerization". United States. https://www.osti.gov/servlets/purl/1028779.
@article{osti_1028779,
title = {Synthetic peptides that cause F-actin bundling and block actin depolymerization},
author = {Sederoff, Heike and Huber, Steven C and Larabell, Carolyn A},
abstractNote = {Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {10}
}
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Works referenced in this record:
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