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Title: Synthetic peptides that cause F-actin bundling and block actin depolymerization

Abstract

Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.

Inventors:
 [1];  [2];  [3]
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  1. Raleigh, NC
  2. Savoy, IL
  3. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1028779
Patent Number(s):
8039438
Application Number:
10/576,757
Assignee:
The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
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DOE Contract Number:  
AC03-76SF00098; AI01-91ER20031
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Sederoff, Heike, Huber, Steven C, and Larabell, Carolyn A. Synthetic peptides that cause F-actin bundling and block actin depolymerization. United States: N. p., 2011. Web.
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Sederoff, Heike, Huber, Steven C, & Larabell, Carolyn A. Synthetic peptides that cause F-actin bundling and block actin depolymerization. United States.
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Sederoff, Heike, Huber, Steven C, and Larabell, Carolyn A. Tue . "Synthetic peptides that cause F-actin bundling and block actin depolymerization". United States. https://www.osti.gov/servlets/purl/1028779.
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@article{osti_1028779,
title = {Synthetic peptides that cause F-actin bundling and block actin depolymerization},
author = {Sederoff, Heike and Huber, Steven C and Larabell, Carolyn A},
abstractNote = {Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {10}
}
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Works referenced in this record:

Biochemical, Physiological, and Molecular Characterization of Sucrose Synthase from Daucus carota
journal, May 1995

Identification of sucrose synthase as an actin-binding protein
journal, July 1998

Complete Nucleotide Sequence of the Maize (Zea mays L.) Sucrose Synthase 2 cDNA
journal, January 1994

A peptide carrier for the delivery of biologically active proteins into mammalian cells
journal, December 2001

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