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Title: Hydroxyapatite-binding peptides for bone growth and inhibition

Abstract

Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.

Inventors:
 [1];  [2];  [3]
  1. Berkeley, CA
  2. Shrewsbury, MA
  3. Walnut Creek, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1027207
Patent Number(s):
8022040
Application Number:
11/720,427
Assignee:
LBNL
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
DOE Contract Number:  
AC03-76SF00098; AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Bertozzi, Carolyn R, Song, Jie, and Lee, Seung-Wuk. Hydroxyapatite-binding peptides for bone growth and inhibition. United States: N. p., 2011. Web.
Bertozzi, Carolyn R, Song, Jie, & Lee, Seung-Wuk. Hydroxyapatite-binding peptides for bone growth and inhibition. United States.
Bertozzi, Carolyn R, Song, Jie, and Lee, Seung-Wuk. Tue . "Hydroxyapatite-binding peptides for bone growth and inhibition". United States. https://www.osti.gov/servlets/purl/1027207.
@article{osti_1027207,
title = {Hydroxyapatite-binding peptides for bone growth and inhibition},
author = {Bertozzi, Carolyn R and Song, Jie and Lee, Seung-Wuk},
abstractNote = {Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {9}
}

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Works referenced in this record:

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