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Title: Monolithic multinozzle emitters for nanoelectrospray mass spectrometry

Abstract

Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM.sup.2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M.sup.3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.

Inventors:
 [1];  [2];  [3];  [4]
  1. Daly City, CA
  2. Kensington, CA
  3. Seoul, KR
  4. Pasadena, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1027205
Patent Number(s):
8022361
Application Number:
12/298,905
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Wang, Daojing, Yang, Peidong, Kim, Woong, and Fan, Rong. Monolithic multinozzle emitters for nanoelectrospray mass spectrometry. United States: N. p., 2011. Web.
Wang, Daojing, Yang, Peidong, Kim, Woong, & Fan, Rong. Monolithic multinozzle emitters for nanoelectrospray mass spectrometry. United States.
Wang, Daojing, Yang, Peidong, Kim, Woong, and Fan, Rong. Tue . "Monolithic multinozzle emitters for nanoelectrospray mass spectrometry". United States. https://www.osti.gov/servlets/purl/1027205.
@article{osti_1027205,
title = {Monolithic multinozzle emitters for nanoelectrospray mass spectrometry},
author = {Wang, Daojing and Yang, Peidong and Kim, Woong and Fan, Rong},
abstractNote = {Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM.sup.2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M.sup.3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {9}
}

Works referenced in this record:

The Chemistry and Physics of Semiconductor Nanowires
journal, February 2005


Parametric studies of electrohydrodynamic spraying.
journal, March 1968


Rendering SU-8 hydrophilic to facilitate use in micro channel fabrication
journal, August 2004


Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells
journal, July 2004


Chip-based nanoelectrospray mass spectrometry for protein characterization
journal, December 2004


Block-by-Block Growth of Single-Crystalline Si/SiGe Superlattice Nanowires
journal, February 2002


Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI?
journal, May 2003


DNA Translocation in Inorganic Nanotubes
journal, September 2005


Room-Temperature Ultraviolet Nanowire Nanolasers
journal, June 2001


Molecular Beams of Macroions
journal, September 1968


Ordered Silicon Nanocavity Arrays in Surface-Assisted Desorption/Ionization Mass Spectrometry
journal, February 2005


Giant Magnetoresistance in Transition Metal Oxides
journal, April 1996


Single-crystal gallium nitride nanotubes
journal, April 2003


Electrospraying from nanofluidic capillary slot
journal, September 2005


Proteomic Profiling of Bone Marrow Mesenchymal Stem Cells upon Transforming Growth Factor β1 Stimulation
journal, August 2004


One-Dimensional Protein Analysis of an HT29 Human Colon Adenocarcinoma Cell
journal, January 2000


Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons
journal, October 1988


Mass spectrometry-based proteomics
journal, March 2003


Proteomics: the first decade and beyond
journal, March 2003


A Fully Integrated Monolithic Microchip Electrospray Device for Mass Spectrometry
journal, September 2000


Desorption/Ionization on Silicon Nanowires
journal, March 2005


Nanoelectrospray—More than just a minimized-flow electrospray ionization source
journal, April 1999


Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS
journal, June 2005


A new on-chip ESI nozzle for coupling of MS with microfluidic devices
journal, January 2004


Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
journal, August 2001


Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last?
journal, September 1994


Nanoliter Chemistry Combined with Mass Spectrometry for Peptide Mapping of Proteins from Single Mammalian Cell Lysates
journal, December 1998


Single-cell MALDI: a new tool for direct peptide profiling
journal, April 2000


Quantum Dot Superlattice Thermoelectric Materials and Devices
journal, September 2002


Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
journal, November 2003


Semiconductor Clusters, Nanocrystals, and Quantum Dots
journal, February 1996


Microfabricated PDMS multichannel emitter for electrospray ionization mass spectrometry
journal, April 2001


Development of micromachined hollow tips for protein analysis based on nanoelectrospray ionization mass spectrometry
journal, August 2002


Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometry
journal, August 1988


Desorption–ionization mass spectrometry on porous silicon
journal, May 1999


The current emitted by highly conducting Taylor cones
journal, February 1994


Carbon Nanotube Single-Electron Transistors at Room Temperature
journal, July 2001


Imaging Mass Spectrometry: Principles and Potentials
journal, January 2005


On the evaporation of small ions from charged droplets
journal, January 1976


A planar microfabricated nanoelectrospray emitter tip based on a capillary slot
journal, November 2003


SEMICONDUCTOR NANOWIRES AND NANOTUBES
journal, August 2004


Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
journal, January 2005


Charge and fission of droplets in electrostatic sprays
journal, January 1994


Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989


Analytical Properties of the Nanoelectrospray Ion Source
journal, January 1996


Electrostatic Control of Ions and Molecules in Nanofluidic Transistors
journal, May 2005


Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array
journal, May 2005


Polarity Switching and Transient Responses in Single Nanotube Nanofluidic Transistors
journal, August 2005


A Micromachined Chip-Based Electrospray Source for Mass Spectrometry
journal, January 2000


Ultrasensitive and Quantitative Analyses from Combined Separations−Mass Spectrometry for the Characterization of Proteomes
journal, April 2004


Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets
journal, June 2006


Nanoribbon Waveguides for Subwavelength Photonics Integration
journal, August 2004