Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism
Abstract
A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency .omega..sub.1, a second light source for providing a second train of pulses at a second center optical frequency .omega..sub.2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.
- Inventors:
-
- Lexington, MA
- Boston, MA
- Cambridge, MA
- Issue Date:
- Research Org.:
- President & Fellows of Harvard College (Cambridge, MA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1027112
- Patent Number(s):
- 8027032
- Application Number:
- 12/196,746
- Assignee:
- President & Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT
- DOE Contract Number:
- FG02-07ER15875
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism. United States: N. p., 2011.
Web.
Xie, Xiaoliang Sunney, Freudiger, Christian, & Min, Wei. Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism. United States.
Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Tue .
"Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism". United States. https://www.osti.gov/servlets/purl/1027112.
@article{osti_1027112,
title = {Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism},
author = {Xie, Xiaoliang Sunney and Freudiger, Christian and Min, Wei},
abstractNote = {A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency .omega..sub.1, a second light source for providing a second train of pulses at a second center optical frequency .omega..sub.2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {9}
}
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Works referenced in this record:
The Stimulated Raman Effect
journal, November 1967
- Bloembergen, N.
- American Journal of Physics, Vol. 35, Issue 11
Coherent Raman gain spectroscopy using CW laser sources
journal, March 1978
- Owyoung, A.
- IEEE Journal of Quantum Electronics, Vol. 14, Issue 3
FM spectroscopy detection of stimulated Raman gain
journal, January 1983
- Levenson, M. D.; Moerner, W. E.; Horne, D. E.
- Optics Letters, Vol. 8, Issue 2
Ultrahigh sensitivity stimulated Raman gain spectroscopy
journal, January 1980
- Levine, B.; Bethea, C.
- IEEE Journal of Quantum Electronics, Vol. 16, Issue 1
Frequency‐modulated shot noise limited stimulated Raman gain spectroscopy
journal, February 1980
- Levine, B. F.; Bethea, C. G.
- Applied Physics Letters, Vol. 36, Issue 4
Surface vibrational spectroscopy using stimulated Raman scattering
journal, December 1979
- Levine, B.; Shank, C.; Heritage, J.
- IEEE Journal of Quantum Electronics, Vol. 15, Issue 12
Femtosecond stimulated Raman microscopy
journal, April 2007
- Ploetz, E.; Laimgruber, S.; Berner, S.
- Applied Physics B, Vol. 87, Issue 3
Inverse Raman spectroscopy in dye solutions with synchronized cw picosecond lasers
journal, October 1984
- Saikan, S.; Hashimoto, N.; Kushida, T.
- Optics Communications, Vol. 51, Issue 6
High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy
journal, January 2006
- Ganikhanov, Feruz; Evans, Conor L.; Saar, Brian G.
- Optics Letters, Vol. 31, Issue 12
Sensitivity limitations for CW stimulated Raman spectroscopy
journal, September 1977
- Owyoung, Adelbert
- Optics Communications, Vol. 22, Issue 3