Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI
Abstract
An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
- Inventors:
-
- Oakland, CA
- Los Alamos, NM
- El Cerrito, CA
- Plainsboro, NJ
- Boulder, CO
- Berkeley, CA
- Houston, TX
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1025887
- Patent Number(s):
- 7994783
- Application Number:
- 12/367,292
- Assignee:
- The Regents of the Univerisity of California (Oakland, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Citation Formats
Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, and Pines, Alexander. Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI. United States: N. p., 2011.
Web.
Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, & Pines, Alexander. Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI. United States.
Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, and Pines, Alexander. Tue .
"Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI". United States. https://www.osti.gov/servlets/purl/1025887.
@article{osti_1025887,
title = {Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI},
author = {Ledbetter, Micah P and Savukov, Igor M and Budker, Dmitry and Shah, Vishal K and Knappe, Svenja and Kitching, John and Michalak, David J and Xu, Shoujun and Pines, Alexander},
abstractNote = {An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {8}
}
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