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Title: Fermentation process using specific oxygen uptake rates as a process control

Abstract

Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

Inventors:
 [1];  [2];  [3]
  1. Minnetonka, MN
  2. Maple Grove, MN
  3. Minneapolis, MN
Issue Date:
Research Org.:
Cargill Inc. (Wayzata, MN)
Sponsoring Org.:
USDOE
OSTI Identifier:
1021878
Patent Number(s):
7,939,298
Application Number:
11/707,188
Assignee:
Cargill Inc. (Wayzata, MN)
DOE Contract Number:  
FC36-00GO10598
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Van Hoek, Pim, Aristidou, Aristos, and Rush, Brian. Fermentation process using specific oxygen uptake rates as a process control. United States: N. p., 2011. Web.
Van Hoek, Pim, Aristidou, Aristos, & Rush, Brian. Fermentation process using specific oxygen uptake rates as a process control. United States.
Van Hoek, Pim, Aristidou, Aristos, and Rush, Brian. Tue . "Fermentation process using specific oxygen uptake rates as a process control". United States. https://www.osti.gov/servlets/purl/1021878.
@article{osti_1021878,
title = {Fermentation process using specific oxygen uptake rates as a process control},
author = {Van Hoek, Pim and Aristidou, Aristos and Rush, Brian},
abstractNote = {Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {5}
}

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Works referenced in this record:

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journal, September 1999


Efficient Homolactic Fermentation by Kluyveromyces lactis Strains Defective in Pyruvate Utilization and Transformed with the Heterologous LDH Gene
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Large scale production of cyclohexanone monooxygenase from Escherichia coli TOP10 pQR239
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