Isotopically labeled compositions and method

Schmidt, Jurgen G; Kimball, David B; Alvarez, Marc A; Williams, Robert F; Martinez, Rudolfo A

Title: Isotopically labeled compositions and method

Abstract

Compounds having stable isotopes .sup.13C and/or .sup.2H were synthesized from precursor compositions having solid phase supports or affinity tags.

Inventors:

Schmidt, Jurgen G ^[1]; Kimball, David B ^[1]; Alvarez, Marc A ^[2]; Williams, Robert F ^[1]; Martinez, Rudolfo A ^[2]

Los Alamos, NM
Santa Fe, NM

Issue Date:: 2011-07-12

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1019428

Patent Number(s):: 7977102

Application Number:: US Patent Application 11/818,984

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C317/22 - with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/13 - Tracers or tags

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C317/44 - having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
C07C323/20 - with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25375 - Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C323/52 - the carbon skeleton being acyclic and saturated
C07C391/02 - having selenium atoms bound to carbon atoms of six-membered aromatic rings

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B2200/05 - Isotopically modified compounds, e.g. labelled

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C323/36 - the sulfur atom of the sulfide group being further bound to an acyclic carbon atom
C07C2602/10 - the other ring being six-membered, e.g. tetraline
C07C2603/24 - Anthracenes

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B2200/11 - Compounds covalently bound to a solid support

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C2602/08 - the other ring being five-membered, e.g. indane
C07C323/60 - with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07C323/32 - having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07B - GENERAL METHODS OF ORGANIC CHEMISTRY
C07B59/001 - {Acyclic or carbocyclic compounds}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C323/21 - with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system

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DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Schmidt, Jurgen G, Kimball, David B, Alvarez, Marc A, Williams, Robert F, and Martinez, Rudolfo A. Isotopically labeled compositions and method.  United States: N. p., 2011. 
        Web.

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                    Schmidt, Jurgen G, Kimball, David B, Alvarez, Marc A, Williams, Robert F, & Martinez, Rudolfo A. Isotopically labeled compositions and method.  United States.

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                    Schmidt, Jurgen G, Kimball, David B, Alvarez, Marc A, Williams, Robert F, and Martinez, Rudolfo A. Tue .  
        "Isotopically labeled compositions and method".  United States.  https://www.osti.gov/servlets/purl/1019428.

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@article{osti_1019428,

  title        = {Isotopically labeled compositions and method},

  author       = {Schmidt, Jurgen G and Kimball, David B and Alvarez, Marc A and Williams, Robert F and Martinez, Rudolfo A},

  abstractNote = {Compounds having stable isotopes .sup.13C and/or .sup.2H were synthesized from precursor compositions having solid phase supports or affinity tags.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {7}

}

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Works referenced in this record:

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones
journal, January 1996

Rayner, Christopher M.
Contemporary Organic Synthesis, Vol. 3, Issue 6
https://doi.org/10.1039/co9960300499

Synthetic applications of fluorous solid-phase extraction (F-SPE)
journal, December 2006

Zhang, Wei; Curran, Dennis P.
Tetrahedron, Vol. 62, Issue 51
https://doi.org/10.1016/j.tet.2006.08.051

Synthesis of thiols, sulfides, sulfoxides and sulfones
journal, January 1995

Rayner, Christopher M.
Contemporary Organic Synthesis, Vol. 2, Issue 6
https://doi.org/10.1039/co9950200409

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones
journal, January 1998

Baird, Charlotte P.; Rayner, Christopher M.
Journal of the Chemical Society, Perkin Transactions 1, Issue 12
https://doi.org/10.1039/a801333k

Isotope or mass encoding of combinatorial libraries
journal, August 1996

Geysen, H. Mario; Wagner, Craig D.; Bodnar, Wanda M.
Chemistry & Biology, Vol. 3, Issue 8
https://doi.org/10.1016/S1074-5521(96)90136-2

Thiols, sulfides, sulfoxides, and sulfones
journal, January 1994

Rayner, Christopher M.
Contemporary Organic Synthesis, Vol. 1, Issue 3
https://doi.org/10.1039/co9940100191

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Similar Records

Title: Isotopically labeled compositions and method

Abstract

Citation Formats

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones journal, January 1996

Synthetic applications of fluorous solid-phase extraction (F-SPE) journal, December 2006

Synthesis of thiols, sulfides, sulfoxides and sulfones journal, January 1995

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones journal, January 1998

Isotope or mass encoding of combinatorial libraries journal, August 1996

Thiols, sulfides, sulfoxides, and sulfones journal, January 1994

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones
journal, January 1996

Synthetic applications of fluorous solid-phase extraction (F-SPE)
journal, December 2006

Synthesis of thiols, sulfides, sulfoxides and sulfones
journal, January 1995

Synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones
journal, January 1998

Isotope or mass encoding of combinatorial libraries
journal, August 1996

Thiols, sulfides, sulfoxides, and sulfones
journal, January 1994