Single nanoparticle tracking spectroscopic microscope

Yang, Haw; Cang, Hu; Xu, Cangshan; Wong, Chung M

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Title: Single nanoparticle tracking spectroscopic microscope

Abstract

A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

Inventors:

Yang, Haw ^[1]; Cang, Hu ^[2]; Xu, Cangshan ^[2]; Wong, Chung M ^[3]

Moraga, CA
Berkeley, CA
San Gabriel, CA

Issue Date:: 2011-07-19

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1019417

Patent Number(s):: 7982194

Application Number:: US Patent Application 12/144,514

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y35/00 - Methods or apparatus for measurement or analysis of nanostructures

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT
G01J3/4406 - {Fluorescence spectrometry}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N15/1463 - {using image analysis for extracting features of the particle}
G01N2015/0038 - {Investigating nanoparticles}

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Yang, Haw, Cang, Hu, Xu, Cangshan, and Wong, Chung M. Single nanoparticle tracking spectroscopic microscope.  United States: N. p., 2011. 
        Web.

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                    Yang, Haw, Cang, Hu, Xu, Cangshan, & Wong, Chung M. Single nanoparticle tracking spectroscopic microscope.  United States.

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                    Yang, Haw, Cang, Hu, Xu, Cangshan, and Wong, Chung M. Tue .  
        "Single nanoparticle tracking spectroscopic microscope".  United States.  https://www.osti.gov/servlets/purl/1019417.

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@article{osti_1019417,

  title        = {Single nanoparticle tracking spectroscopic microscope},

  author       = {Yang, Haw and Cang, Hu and Xu, Cangshan and Wong, Chung M},

  abstractNote = {A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {7}

}

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Works referenced in this record:

Control of Nanoparticles with Arbitrary Two-Dimensional Force Fields
journal, March 2005

Cohen, Adam E.
Physical Review Letters, Vol. 94, Issue 11
https://doi.org/10.1103/PhysRevLett.94.118102

How to Track Bacteria
journal, June 1971

Berg, Howard C.
Review of Scientific Instruments, Vol. 42, Issue 6
https://doi.org/10.1063/1.1685246

Progress in single-molecule tracking spectroscopy
journal, May 2008

Cang, Hu; Shan Xu, C.; Yang, Haw
Chemical Physics Letters, Vol. 457, Issue 4-6
https://doi.org/10.1016/j.cplett.2008.03.098

Three dimensional single-particle tracking with nanometer resolution
journal, July 1998

Peters, Inge M.; de Grooth, Bart G.; Schins, Juleon M.
Review of Scientific Instruments, Vol. 69, Issue 7
https://doi.org/10.1063/1.1149012

High-throughput scanning confocal microscope for single molecule analysis
journal, February 2004

Sabanayagam, Chandran R.; Eid, John S.; Meller, Amit
Applied Physics Letters, Vol. 84, Issue 7
https://doi.org/10.1063/1.1646725

Tracking of fluorescent molecules diffusing within membranes
journal, November 2000

Enderlein, J.
Applied Physics B, Vol. 71, Issue 5
https://doi.org/10.1007/s003400000409

Confocal three dimensional tracking of a single nanoparticle with concurrent spectroscopic readouts
journal, May 2006

Cang, Hu; Wong, Chung M.; Xu, C. Shan
Applied Physics Letters, Vol. 88, Issue 22
https://doi.org/10.1063/1.2204652

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Similar Records

Title: Single nanoparticle tracking spectroscopic microscope

Abstract

Citation Formats

Control of Nanoparticles with Arbitrary Two-Dimensional Force Fields journal, March 2005

How to Track Bacteria journal, June 1971

Progress in single-molecule tracking spectroscopy journal, May 2008

Three dimensional single-particle tracking with nanometer resolution journal, July 1998

High-throughput scanning confocal microscope for single molecule analysis journal, February 2004

Tracking of fluorescent molecules diffusing within membranes journal, November 2000

Confocal three dimensional tracking of a single nanoparticle with concurrent spectroscopic readouts journal, May 2006

Control of Nanoparticles with Arbitrary Two-Dimensional Force Fields
journal, March 2005

How to Track Bacteria
journal, June 1971

Progress in single-molecule tracking spectroscopy
journal, May 2008

Three dimensional single-particle tracking with nanometer resolution
journal, July 1998

High-throughput scanning confocal microscope for single molecule analysis
journal, February 2004

Tracking of fluorescent molecules diffusing within membranes
journal, November 2000

Confocal three dimensional tracking of a single nanoparticle with concurrent spectroscopic readouts
journal, May 2006