Peptides whose uptake by cells is controllable

Jiang, Tao; Olson, Emilia S; Whitney, Michael; Tsien, Roger

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
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Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:

Jiang, Tao ^[1]; Olson, Emilia S ^[2]; Whitney, Michael ^[1]; Tsien, Roger ^[2]

San Diego, CA
La Jolla, CA

Issue Date:: 2011-07-26

Research Org.:: University of California (Oakland, CA)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1019404

Patent Number(s):: 7985401

Application Number:: US Patent Application 11/133,804

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K47/645 - {Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT}
A61K47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K49/0032 - {Methine dyes, e.g. cyanine dyes}
A61K49/0043 - {Fluorescein, used in vivo}
A61K49/0056 - {Peptides, proteins, polyamino acids}
A61K49/085 - {conjugated systems}
A61K49/14 - Peptides, e.g. proteins
A61K49/146 - {the peptide being a polyamino acid, e.g. poly-lysine}
A61K51/088 - {conjugates with carriers being peptides, polyamino acids, proteins

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/00 - Peptides having more than 20 amino acids
C07K14/4728 - {Calcium binding proteins, e.g. calmodulin}
C07K7/08 - having 12 to 20 amino acids

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DOE Contract Number:: FG03-01ER63276

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Jiang, Tao, Olson, Emilia S, Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable.  United States: N. p., 2011. 
        Web.

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                    Jiang, Tao, Olson, Emilia S, Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable.  United States.

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                    Jiang, Tao, Olson, Emilia S, Whitney, Michael, and Tsien, Roger. Tue .  
        "Peptides whose uptake by cells is controllable".  United States.  https://www.osti.gov/servlets/purl/1019404.

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@article{osti_1019404,

  title        = {Peptides whose uptake by cells is controllable},

  author       = {Jiang, Tao and Olson, Emilia S and Whitney, Michael and Tsien, Roger},

  abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {7}

}

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Works referenced in this record:

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
journal, October 1999

Golub, T. R.
Science, Vol. 286, Issue 5439, p. 531-537
https://doi.org/10.1126/science.286.5439.531

Tumor imaging by means of proteolytic activation of cell-penetrating peptides
journal, December 2004

Jiang, T.; Olson, E. S.; Nguyen, Q. T.
Proceedings of the National Academy of Sciences, Vol. 101, Issue 51, p. 17867-17872
https://doi.org/10.1073/pnas.0408191101

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney: VI. Specificity: Amino acids, their N-methyl-, N-acetyl- and N-benzoylderivatives; glutathione- and cysteine conjugates, di- and oligopeptides
journal, December 1989

Ullrich, K. J.; Rumrich, G.; Wieland, Th.
Pfl�gers Archiv European Journal of Physiology, Vol. 415, Issue 3
https://doi.org/10.1007/BF00370886

Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide
journal, May 2000

Bhorade, Rajeev; Weissleder, Ralph; Nakakoshi, Tsunenori
Bioconjugate Chemistry, Vol. 11, Issue 3
https://doi.org/10.1021/bc990168d

Visualizing the mechanical activation of Src
journal, April 2005

Wang, Yingxiao; Botvinick, Elliot L.; Zhao, Yihua
Nature, Vol. 434, Issue 7036
https://doi.org/10.1038/nature03469

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Peptides whose uptake by cells is controllable

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A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability ofmore » « less
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A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. Cleavage of X allows separation of A from B, unmasking the normal ability ofmore » « less
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Similar Records

Title: Peptides whose uptake by cells is controllable

Abstract

Citation Formats

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring journal, October 1999

Tumor imaging by means of proteolytic activation of cell-penetrating peptides journal, December 2004

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney: VI. Specificity: Amino acids, their N-methyl-, N-acetyl- and N-benzoylderivatives; glutathione- and cysteine conjugates, di- and oligopeptides journal, December 1989

Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide journal, May 2000

Visualizing the mechanical activation of Src journal, April 2005

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
journal, October 1999

Tumor imaging by means of proteolytic activation of cell-penetrating peptides
journal, December 2004

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney: VI. Specificity: Amino acids, their N-methyl-, N-acetyl- and N-benzoylderivatives; glutathione- and cysteine conjugates, di- and oligopeptides
journal, December 1989

Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide
journal, May 2000

Visualizing the mechanical activation of Src
journal, April 2005