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Title: Genomic library construction

Abstract

Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided.

Inventors:
 [1];  [2]
  1. Brookline, MA
  2. San Diego, CA
Issue Date:
Research Org.:
Harvard University
Sponsoring Org.:
USDOE
OSTI Identifier:
1019402
Patent Number(s):
7985546
Application Number:
US Patent Application 12/265,184
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Church, George M, and Zhang, Kun. Genomic library construction. United States: N. p., 2011. Web.
Church, George M, & Zhang, Kun. Genomic library construction. United States.
Church, George M, and Zhang, Kun. Tue . "Genomic library construction". United States. https://www.osti.gov/servlets/purl/1019402.
@article{osti_1019402,
title = {Genomic library construction},
author = {Church, George M and Zhang, Kun},
abstractNote = {Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {7}
}

Patent:

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Works referenced in this record:

Mutation detection and single-molecule counting using isothermal rolling-circleamplification
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Genomic DNA Amplification from a Single Bacterium
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Isothermal Strand-Displacement Amplification Applications for High-Throughput Genomics
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Ligation overcomes terminal underrepresentation in multiple displacement amplification of linear DNA
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Fine-scale phylogenetic architecture of a complex bacterial community
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Advanced sequencing technologies: methods and goals
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Comprehensive human genome amplification using multiple displacement amplification
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Whole genome amplification from a single cell: implications for genetic analysis.
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Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer
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Isothermal Amplification and Multimerization of DNA by Bst DNA Polymerase
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Cell-free cloning using φ29 DNA polymerase
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Unbiased Whole-Genome Amplification Directly From Clinical Samples
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Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome
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Isothermal in vitro amplification of DNA by a restriction enzyme/DNA polymerase system.
journal, January 1992