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Title: Fiducial marker for correlating images

Abstract

The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or usingmore » extrinsic labels or stains.

Inventors:
 [1];  [2];  [3];  [4]
  1. Rocky Point, NY
  2. Wading River, NY
  3. Port Jefferson, NY
  4. Hampton Bays, NY
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1019083
Patent Number(s):
7965820
Application Number:
US Patent Application 12/191,525
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
97 MATHEMATICS AND COMPUTING

Citation Formats

Miller, Lisa Marie, Smith, Randy J, Warren, John B, and Elliott, Donald. Fiducial marker for correlating images. United States: N. p., 2011. Web.
Miller, Lisa Marie, Smith, Randy J, Warren, John B, & Elliott, Donald. Fiducial marker for correlating images. United States.
Miller, Lisa Marie, Smith, Randy J, Warren, John B, and Elliott, Donald. Tue . "Fiducial marker for correlating images". United States. https://www.osti.gov/servlets/purl/1019083.
@article{osti_1019083,
title = {Fiducial marker for correlating images},
author = {Miller, Lisa Marie and Smith, Randy J and Warren, John B and Elliott, Donald},
abstractNote = {The invention relates to a fiducial marker having a marking grid that is used to correlate and view images produced by different imaging modalities or different imaging and viewing modalities. More specifically, the invention relates to the fiducial marking grid that has a grid pattern for producing either a viewing image and/or a first analytical image that can be overlaid with at least one other second analytical image in order to view a light path or to image different imaging modalities. Depending on the analysis, the grid pattern has a single layer of a certain thickness or at least two layers of certain thicknesses. In either case, the grid pattern is imageable by each imaging or viewing modality used in the analysis. Further, when viewing a light path, the light path of the analytical modality cannot be visualized by viewing modality (e.g., a light microscope objective). By correlating these images, the ability to analyze a thin sample that is, for example, biological in nature but yet contains trace metal ions is enhanced. Specifically, it is desired to analyze both the organic matter of the biological sample and the trace metal ions contained within the biological sample without adding or using extrinsic labels or stains.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {6}
}

Works referenced in this record:

A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissues
journal, November 2006


Development and applications of an epifluorescence module for synchrotron x-ray fluorescence microprobe imaging
journal, June 2005