Method for redesign of microbial production systems
Abstract
A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.
- Inventors:
-
- Port Matilda, PA
- State College, PA
- Issue Date:
- Research Org.:
- The Penn State Research Foundation (University Park, PA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1017455
- Patent Number(s):
- 7826975
- Application Number:
- 10/929,091
- Assignee:
- The Penn State Research Foundation (University Park, PA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- DOE Contract Number:
- 58855
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Maranas, Costas D, Burgard, Anthony P, and Pharkya, Priti. Method for redesign of microbial production systems. United States: N. p., 2010.
Web.
Maranas, Costas D, Burgard, Anthony P, & Pharkya, Priti. Method for redesign of microbial production systems. United States.
Maranas, Costas D, Burgard, Anthony P, and Pharkya, Priti. Tue .
"Method for redesign of microbial production systems". United States. https://www.osti.gov/servlets/purl/1017455.
@article{osti_1017455,
title = {Method for redesign of microbial production systems},
author = {Maranas, Costas D and Burgard, Anthony P and Pharkya, Priti},
abstractNote = {A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {11}
}
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