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Title: SERS molecular probe for diagnostics and therapy and methods of use thereof

Abstract

An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.

Inventors:
 [1]
  1. Knoxville, TN
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1016828
Patent Number(s):
7951535
Application Number:
11/972,110
Assignee:
U-T Battelle, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Jan 10
Country of Publication:
United States
Language:
English

Citation Formats

Vo-Dinh, Tuan. SERS molecular probe for diagnostics and therapy and methods of use thereof. United States: N. p., 0011. Web.
Vo-Dinh, Tuan. SERS molecular probe for diagnostics and therapy and methods of use thereof. United States.
Vo-Dinh, Tuan. Sun . "SERS molecular probe for diagnostics and therapy and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1016828.
@article{osti_1016828,
title = {SERS molecular probe for diagnostics and therapy and methods of use thereof},
author = {Vo-Dinh, Tuan},
abstractNote = {An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {0011},
month = {5}
}