SERS molecular probe for diagnostics and therapy and methods of use thereof
Abstract
An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1016828
- Patent Number(s):
- 7951535
- Application Number:
- 11/972,110
- Assignee:
- U-T Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2008 Jan 10
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Vo-Dinh, Tuan. SERS molecular probe for diagnostics and therapy and methods of use thereof. United States: N. p., 0011.
Web.
Vo-Dinh, Tuan. SERS molecular probe for diagnostics and therapy and methods of use thereof. United States.
Vo-Dinh, Tuan. Sun .
"SERS molecular probe for diagnostics and therapy and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1016828.
@article{osti_1016828,
title = {SERS molecular probe for diagnostics and therapy and methods of use thereof},
author = {Vo-Dinh, Tuan},
abstractNote = {An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {0011},
month = {5}
}
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