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Title: Inorganic resins for clinical use of .sup.213Bi generators

Abstract

Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly .sup.213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of .sup.213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.

Inventors:
 [1];  [1];  [1];  [2]
  1. Knoxville, TN
  2. Elizabethton, TN
Issue Date:
Research Org.:
UT-Battelle LLC (Oak Ridge, TN)
Sponsoring Org.:
USDOE
OSTI Identifier:
1015585
Patent Number(s):
7914766
Application Number:
US Patent Application 10/860,520
Assignee:
UT-Battelle LLC (Oak Ridge, TN)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, and Clavier, John W. Inorganic resins for clinical use of .sup.213Bi generators. United States: N. p., 2011. Web.
DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, & Clavier, John W. Inorganic resins for clinical use of .sup.213Bi generators. United States.
DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, and Clavier, John W. Tue . "Inorganic resins for clinical use of .sup.213Bi generators". United States. https://www.osti.gov/servlets/purl/1015585.
@article{osti_1015585,
title = {Inorganic resins for clinical use of .sup.213Bi generators},
author = {DePaoli, David W and Hu, Michael Z and Mirzadeh, Saed and Clavier, John W},
abstractNote = {Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly .sup.213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of .sup.213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}

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Works referenced in this record:

An Improved Generator for the Production of 213Bi from 225Ac
journal, January 1997


Templating of Mesoporous Molecular Sieves by Nonionic Polyethylene Oxide Surfactants
journal, September 1995


Double pore silica gel monolith applied to liquid chromatography
journal, February 1997


The Sol-Gel Preparation of Silica Gels
journal, July 1994


A new family of mesoporous molecular sieves prepared with liquid crystal templates
journal, December 1992


Optimizations of Radiolabeling of Immunoproteins with 213Bi
journal, January 1997


Development of a Unique Bismuth (Bi-213) Automated Generator for Use in Cancer Therapy
journal, September 2000


The feasibility of 225 Ac as a source of ??-particles in radioimmunotherapy
journal, January 1993


Radionuclides for Radioimmunotherapy: Criteria for Selection
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The sol-gel process
journal, January 1990


A review of the radiation stability of ion exchange materials
journal, November 1986