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Title: Inorganic resins for clinical use of .sup.213Bi generators

Abstract

Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly .sup.213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of .sup.213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.

Inventors:
 [1];  [1];  [1];  [2]
  1. Knoxville, TN
  2. Elizabethton, TN
Issue Date:
Research Org.:
UT-Battelle LLC (Oak Ridge, TN)
Sponsoring Org.:
USDOE
OSTI Identifier:
1015585
Patent Number(s):
7,914,766
Application Number:
US Patent Application 10/860,520
Assignee:
UT-Battelle LLC (Oak Ridge, TN) ORO
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, and Clavier, John W. Inorganic resins for clinical use of .sup.213Bi generators. United States: N. p., 2011. Web.
DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, & Clavier, John W. Inorganic resins for clinical use of .sup.213Bi generators. United States.
DePaoli, David W, Hu, Michael Z, Mirzadeh, Saed, and Clavier, John W. Tue . "Inorganic resins for clinical use of .sup.213Bi generators". United States. https://www.osti.gov/servlets/purl/1015585.
@article{osti_1015585,
title = {Inorganic resins for clinical use of .sup.213Bi generators},
author = {DePaoli, David W and Hu, Michael Z and Mirzadeh, Saed and Clavier, John W},
abstractNote = {Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly .sup.213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of .sup.213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}

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