Inorganic resins for clinical use of 213Bi generators
Abstract
Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly 213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of 213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.
- Inventors:
-
- Knoxville, TN
- Elizabethton, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1015585
- Patent Number(s):
- 7914766
- Application Number:
- 10/860,520
- Assignee:
- UT-Battelle LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2004 Jun 03
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE
Citation Formats
DePaoli, David W., Hu, Michael Z., Mirzadeh, Saed, and Clavier, John W. Inorganic resins for clinical use of 213Bi generators. United States: N. p., 2011.
Web.
DePaoli, David W., Hu, Michael Z., Mirzadeh, Saed, & Clavier, John W. Inorganic resins for clinical use of 213Bi generators. United States.
DePaoli, David W., Hu, Michael Z., Mirzadeh, Saed, and Clavier, John W. Tue .
"Inorganic resins for clinical use of 213Bi generators". United States. https://www.osti.gov/servlets/purl/1015585.
@article{osti_1015585,
title = {Inorganic resins for clinical use of 213Bi generators},
author = {DePaoli, David W. and Hu, Michael Z. and Mirzadeh, Saed and Clavier, John W.},
abstractNote = {Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly 213Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of 213Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 29 00:00:00 EDT 2011},
month = {Tue Mar 29 00:00:00 EDT 2011}
}
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