Ion funnel ion trap and process

Title: Ion funnel ion trap and process

Abstract

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

Inventors:

Belov, Mikhail E ^[1]; Ibrahim, Yehia M ^[1]; Clowers, Biran H ^[2]; Prior, David C ^[3]; Smith, Richard D ^[1]

Richland, WA
West Richland, WA
Hermiston, OR

Issue Date:: 2011-02-15

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1015253

Patent Number(s):: 7888635

Application Number:: US Patent Application 12/156,360

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/066 - {Ion funnels}
H01J49/4235 - {Stacked rings or stacked plates}

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DOE Contract Number:: AC05-76RLO1830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Ion funnel ion trap and process.  United States: N. p., 2011. 
        Web.

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                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, & Smith, Richard D. Ion funnel ion trap and process.  United States.

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                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Tue .  
        "Ion funnel ion trap and process".  United States.  https://www.osti.gov/servlets/purl/1015253.

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@article{osti_1015253,

  title        = {Ion funnel ion trap and process},

  author       = {Belov, Mikhail E and Ibrahim, Yehia M and Clowers, Biran H and Prior, David C and Smith, Richard D},

  abstractNote = {An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {2}

}

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Works referenced in this record:

Design of a new electrospray ion mobility mass spectrometer
journal, November 2001

Wyttenbach, Thomas; Kemper, Paul R.; Bowers, Michael T.
International Journal of Mass Spectrometry, Vol. 212, Issue 1-3
https://doi.org/10.1016/S1387-3806(01)00517-6

A Tandem Ion Trap/Ion Mobility Spectrometer
journal, July 2000

Creaser, Colin S.; Benyezzar, Med; Griffiths, John R.
Analytical Chemistry, Vol. 72, Issue 13
https://doi.org/10.1021/ac991409d

Analysis of a drift tube at ambient pressure: Models and precise measurements in ion mobility spectrometry
journal, September 2001

Eiceman, G. A.; Nazarov, E. G.; Rodriguez, J. E.
Review of Scientific Instruments, Vol. 72, Issue 9
https://doi.org/10.1063/1.1392339

Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry
journal, October 2007

Ibrahim, Yehia; Belov, Mikhail E.; Tolmachev, Aleksey V.
Analytical Chemistry, Vol. 79, Issue 20
https://doi.org/10.1021/ac071091m

High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces
journal, May 2005

Tang, Keqi; Shvartsburg, Alexandre A.; Lee, Hak-No
Analytical Chemistry, Vol. 77, Issue 10, p. 3330-3339
https://doi.org/10.1021/ac048315a

An Ion Trap Interface for ESI−Ion Mobility Experiments
journal, October 1997

Hoaglund, Cherokee S.; Valentine, Stephen J.; Clemmer, David E.
Analytical Chemistry, Vol. 69, Issue 20
https://doi.org/10.1021/ac970526a

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Title: Ion funnel ion trap and process

Abstract

Citation Formats

Design of a new electrospray ion mobility mass spectrometer journal, November 2001

A Tandem Ion Trap/Ion Mobility Spectrometer journal, July 2000

Analysis of a drift tube at ambient pressure: Models and precise measurements in ion mobility spectrometry journal, September 2001

Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry journal, October 2007

High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces journal, May 2005

An Ion Trap Interface for ESI−Ion Mobility Experiments journal, October 1997

Design of a new electrospray ion mobility mass spectrometer
journal, November 2001

A Tandem Ion Trap/Ion Mobility Spectrometer
journal, July 2000

Analysis of a drift tube at ambient pressure: Models and precise measurements in ion mobility spectrometry
journal, September 2001

Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry
journal, October 2007

High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces
journal, May 2005

An Ion Trap Interface for ESI−Ion Mobility Experiments
journal, October 1997