Ion funnel ion trap and process

Title: Ion funnel ion trap and process

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Abstract

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

Inventors:

Belov, Mikhail E ^[1]; Ibrahim, Yehia M ^[1]; Clowers, Biran H ^[2]; Prior, David C ^[3]; Smith, Richard D ^[1]

Richland, WA
West Richland, WA
Hermiston, OR

Issue Date:: 2011-02-15

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1015253

Patent Number(s):: 7,888,635

Application Number:: US Patent Application 12/156,360

Assignee:: Battelle Memorial Institute (Richland, WA) RLO

DOE Contract Number:: AC05-76RLO1830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Ion funnel ion trap and process.  United States: N. p., 2011. 
        Web.

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                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, & Smith, Richard D. Ion funnel ion trap and process.  United States.

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                    Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Tue .  
        "Ion funnel ion trap and process".  United States.  https://www.osti.gov/servlets/purl/1015253.

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@article{osti_1015253,

  title        = {Ion funnel ion trap and process},

  author       = {Belov, Mikhail E and Ibrahim, Yehia M and Clowers, Biran H and Prior, David C and Smith, Richard D},

  abstractNote = {An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2011},

  month        = {2}

}

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