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Title: Ion funnel ion trap and process

Abstract

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.

Inventors:
 [1];  [1];  [2];  [3];  [1]
  1. Richland, WA
  2. West Richland, WA
  3. Hermiston, OR
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1015253
Patent Number(s):
7888635
Application Number:
US Patent Application 12/156,360
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
AC05-76RLO1830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Ion funnel ion trap and process. United States: N. p., 2011. Web.
Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, & Smith, Richard D. Ion funnel ion trap and process. United States.
Belov, Mikhail E, Ibrahim, Yehia M, Clowers, Biran H, Prior, David C, and Smith, Richard D. Tue . "Ion funnel ion trap and process". United States. https://www.osti.gov/servlets/purl/1015253.
@article{osti_1015253,
title = {Ion funnel ion trap and process},
author = {Belov, Mikhail E and Ibrahim, Yehia M and Clowers, Biran H and Prior, David C and Smith, Richard D},
abstractNote = {An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {2}
}

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Works referenced in this record:

Design of a new electrospray ion mobility mass spectrometer
journal, November 2001


A Tandem Ion Trap/Ion Mobility Spectrometer
journal, July 2000


Analysis of a drift tube at ambient pressure: Models and precise measurements in ion mobility spectrometry
journal, September 2001


Ion Funnel Trap Interface for Orthogonal Time-of-Flight Mass Spectrometry
journal, October 2007


High-Sensitivity Ion Mobility Spectrometry/Mass Spectrometry Using Electrodynamic Ion Funnel Interfaces
journal, May 2005


An Ion Trap Interface for ESI−Ion Mobility Experiments
journal, October 1997