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Title: Glycoprotein synthesis

Abstract

Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.

Inventors:
 [1];  [2];  [2]
  1. La Jolla, CA
  2. San Diego, CA
Issue Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1014956
Patent Number(s):
7825226
Application Number:
US Patent Application 11/978,232
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Schultz, Peter G, Wang, Lei, and Zhang, Zhiwen. Glycoprotein synthesis. United States: N. p., 2010. Web.
Schultz, Peter G, Wang, Lei, & Zhang, Zhiwen. Glycoprotein synthesis. United States.
Schultz, Peter G, Wang, Lei, and Zhang, Zhiwen. Tue . "Glycoprotein synthesis". United States. https://www.osti.gov/servlets/purl/1014956.
@article{osti_1014956,
title = {Glycoprotein synthesis},
author = {Schultz, Peter G and Wang, Lei and Zhang, Zhiwen},
abstractNote = {Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {11}
}

Patent:

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