Title: Preconcentration and separation of analytes in microchannels

Abstract

Disclosed herein are methods and devices for preconcentrating and separating analytes such as proteins and polynucleotides in microchannels. As disclosed, at least one size-exclusion polymeric element is adjacent to processing area or an assay area in a microchannel which may be porous polymeric element. The size-exclusion polymeric element may be used to manipulate, e.g. concentrate, analytes in a sample prior to assaying in the assay area.

Inventors:

Hatch, Anson ^[1]; Singh, Anup K ^[2]; Herr, Amy E ^[3]; Throckmorton, Daniel J ^[1]

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1. Tracy, CA
2. Danville, CA
3. Fremont, CA

Issue Date:

Tue Nov 09 00:00:00 EST 2010

Research Org.:

Sandia Corporation (Livermore, CA)

Sponsoring Org.:

USDOE

OSTI Identifier:

1014940

Patent Number(s):

7828948

Application Number:

US Patent Application 11/536,753

Assignee:

Sandia Corporation (Livermore, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B01D57/02 - by electrophoresis

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N27/44743 - {Introducing samples}
G01N27/44791 - {Microapparatus

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DOE Contract Number:  

AC04-94AL85000

Resource Type:

Patent

Country of Publication:

United States

Language:

English