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Title: Cleavage of nucleic acids

Abstract

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Inventors:
 [1];  [2];  [1]; ;  [1];  [1]
  1. (Madison, WI)
  2. (Waunakee, WI)
Issue Date:
Research Org.:
Third Wave Technologies, Inc. (Madison, WI)
Sponsoring Org.:
USDOE
OSTI Identifier:
1014935
Patent Number(s):
7,829,314
Application Number:
US Patent Application 12/476,912
Assignee:
Third Wave Technologies, Inc. (Madison, WI) CHO
DOE Contract Number:  
FG02-94ER81891
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Prudent, James R., Hall, Jeff G., Lyamichev, Victor I., Brow, Mary Ann D., and Dahlberg, James E. Cleavage of nucleic acids. United States: N. p., 2010. Web.
Prudent, James R., Hall, Jeff G., Lyamichev, Victor I., Brow, Mary Ann D., & Dahlberg, James E. Cleavage of nucleic acids. United States.
Prudent, James R., Hall, Jeff G., Lyamichev, Victor I., Brow, Mary Ann D., and Dahlberg, James E. Tue . "Cleavage of nucleic acids". United States. https://www.osti.gov/servlets/purl/1014935.
@article{osti_1014935,
title = {Cleavage of nucleic acids},
author = {Prudent, James R. and Hall, Jeff G. and Lyamichev, Victor I. and Brow and Mary Ann D. and Dahlberg, James E.},
abstractNote = {The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {11}
}

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