Acoustic concentration of particles in fluid flow

Ward, Michael D; Kaduchak, Gregory

Title: Acoustic concentration of particles in fluid flow

Abstract

An apparatus for acoustic concentration of particles in a fluid flow includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.

Inventors:

Ward, Michael D ^[1]; Kaduchak, Gregory ^[1]

Los Alamos, NM

Issue Date:: 2010-11-23

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1014872

Patent Number(s):: 7837040

Application Number:: 11/784,936

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION

B - PERFORMING OPERATIONS B07 - SEPARATING SOLIDS FROM SOLIDS B07B - SEPERATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, OR SIFTING OR BY USING GAS CURRENTS

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B01D11/0261 - {comprising vibrating mechanisms, e.g. mechanical, acoustical}
B01D61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration

B - PERFORMING OPERATIONS B07 - SEPARATING SOLIDS FROM SOLIDS B07B - SEPERATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, OR SIFTING OR BY USING GAS CURRENTS
B07B2230/04 - The screen or the screened materials being subjected to ultrasonic vibration

C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
C12M47/02 - {Separating microorganisms from the culture medium

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N1/4077 - {by other techniques involving separation of suspended solids}
G01N2001/4094 - {using ultrasound}

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DOE Contract Number:: AC51-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Apr 09

Country of Publication:: United States

Language:: English

Citation Formats


                    Ward, Michael D, and Kaduchak, Gregory. Acoustic concentration of particles in fluid flow.  United States: N. p., 2010. 
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                    Ward, Michael D, & Kaduchak, Gregory. Acoustic concentration of particles in fluid flow.  United States.

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                    Ward, Michael D, and Kaduchak, Gregory. Tue .  
        "Acoustic concentration of particles in fluid flow".  United States.  https://www.osti.gov/servlets/purl/1014872.

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@article{osti_1014872,

  title        = {Acoustic concentration of particles in fluid flow},

  author       = {Ward, Michael D and Kaduchak, Gregory},

  abstractNote = {An apparatus for acoustic concentration of particles in a fluid flow includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2010},

  month        = {11}

}

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Title: Acoustic concentration of particles in fluid flow

Abstract

Citation Formats

Enhanced sedimentation of mammalian cells following acoustic aggregation journal, August 1989

Development of a novel compact sonicator for cell disruption journal, February 2005

Dual-laser, differential fluorescence correction method for reducing cellular background autofluorescence journal, November 1986

Layered piezoelectric resonators with an arbitrary number of electrodes (general one‐dimensional treatment) journal, September 1991

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer journal, January 2006

Separation of sperm and vaginal cells with flow cytometry for DNA typing after sexual assault journal, October 1999

Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel journal, January 2004

Theory of long wavelength acoustic radiation pressure journal, October 1991

Migration of suspended particles in plane stationary ultrasonic field journal, January 1981

Increasing the luminescence of lanthanide complexes journal, January 2006

Using acoustic radiation force as a concentration method for erythrocytes journal, July 1997

Dynamics of suspended particles in a two-dimensional high-frequency sonic field journal, June 1995

An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection journal, January 2004

Single particle high resolution spectral analysis flow cytometry journal, January 2006

Standing‐wave acoustic trap for nonintrusive positioning of microparticles journal, October 1995

Acoustic separation in a laminar flow conference, January 1994

Generalized rainbows and unfolded glories of oblate drops: organization for multiple internal reflections and extension of cusps into Alexander's dark band journal, January 1994

Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels journal, March 2005

Scanning flow cytometry for individual particle analysis journal, January 2000

Evaluation of SDF-1/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry journal, December 2002

Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width journal, January 2003

Upper sound pressure limits on particle concentration in fields of ultrasonic standing-wave at megahertz frequencies journal, January 1992

Cell–cell contact and membrane spreading in an ultrasound trap journal, April 2004

Separation of dispersed phases from liquids in acoustically driven chambers journal, February 1993

Acoustic concentration of particles in piezoelectric tubes: Theoretical modeling of the effect of cavity shape and symmetry breaking journal, October 2004

Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid journal, December 1994

On the drift of aerosol particles in sonic fields journal, September 1992

Measurement of Mammalian Erythrocyte Indices from Light Scattering with Scaning Flow Cytometer conference, January 2003

Data Analysis for a Dual-Channel Virus Counter journal, April 2005

Manipulation of cells using an ultrasonic pressure field journal, June 2005

Blue LED Excitable Temperature Sensors Based on a New Europium(III) Chelate journal, February 2008

Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy journal, January 1990

Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends journal, July 2004

Spatial light-scattering analysis as a means of characterizing and classifying non-spherical particles journal, February 1998

On the Possibility of Long-Wavelength Long-Lifetime High-Quantum-Yield Luminophores journal, January 2001

Formation and growth of ice particles in stationary ultrasonic fields journal, September 1998

The mean force acting on a small body in an axisymmetric sound field in a real medium journal, January 1987

Plasma preparation from whole blood using ultrasound journal, June 2000

Precise Measurements Of Particle Entrainment In A Standing-Wave Acoustic Field Between 20 And 3500 Hz journal, December 2000

The effect of centreline particle concentration in a wave tube journal, January 1996

Quantum mechanical representation of acoustic streaming and acoustic radiation pressure journal, July 2001

Acoustic filtration and sedimentation of soot particles journal, December 1997

A new immobilisation method to arrange particles in a gel matrix by ultrasound standing waves journal, February 2005

Ultrasonic waves for fabricating lattice structure in composite materials conference, September 1999

Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces journal, January 2005

Acoustically aided separation of oil droplets from aqueous emulsions journal, August 2004

Microparticle manipulation in millimetre scale ultrasonic standing wave chambers journal, August 1998

Light-scattering properties of individual erythrocytes journal, January 1999

Modelling of particle paths passing through an ultrasonic standing wave journal, April 2004

Ultrasonic Micromanipulator Using Visual Feedback journal, May 1996

Acoustic micromanipulation using a multi-electrode transducer conference, January 1996

Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis journal, March 2006

Progress in Lanthanides as Luminescent Probes journal, July 2005

Single particle aerodynamic relaxation time analyzer journal, June 1977

Enhanced synchronized ultrasonic and flow-field fractionation of suspensions journal, March 1994

Batch and semicontinuous aggregation and sedimentation of hybridoma cells by acoustic resonance fields journal, March 1995

The use of ultrasonic standing waves to enhance optical particle sizing equipment journal, March 2000

Ultrasonic trapping of paramecia and estimation of their locomotive force journal, October 1997

Design and characterization of a compact dual channel virus counter journal, January 2005

Cellular platforms for HTS: three case studies journal, March 2002

Resolving leukocytes using axial light loss journal, July 1989

Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis journal, March 2007

Ruthenium(II) complex with a notably long excited state lifetime journal, January 2000

On the Acoustic Radiation Pressure on Spheres journal, November 1934

Transport and harvesting of suspended particles using modulated ultrasound journal, November 1991

Continuous Flow Microfluidic Device for Rapid Erythrocyte Lysis journal, November 2004

A silicon microfluidic ultrasonic separator journal, October 2003

Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results journal, March 2002

Ultrasonic four‐wave mixing mediated by an aqueous suspension of microspheres: Theoretical steady‐state properties journal, September 1995

Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels journal, April 2005

Ultrasonic separations in analytical biotechnology journal, December 1997

Concentration and Fractionation of Small Particles in Liquid by Ultrasound journal, May 1995

Lanthanide-based luminescence probes and time-resolved luminescence bioassays journal, May 2006

Extension of acoustic levitation to include the study of micron‐size particles in a more compressible host liquid journal, May 1982

Separation of a biocatalyst with ultrafiltration or filtration after bioconversion journal, March 1997

Experimental and theoretical study of light scattering by individual mature red blood cells by use of scanning flow cytometry and a discrete dipole approximation journal, January 2005

Control of a Standing Wave Field Using a Line-Focused Transducer for Two-Dimensional Manipulation of Particles journal, May 1998

Enhanced sedimentation of mammalian cells following acoustic aggregation
journal, August 1989

Development of a novel compact sonicator for cell disruption
journal, February 2005

Dual-laser, differential fluorescence correction method for reducing cellular background autofluorescence
journal, November 1986

Layered piezoelectric resonators with an arbitrary number of electrodes (general one‐dimensional treatment)
journal, September 1991

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer
journal, January 2006

Separation of sperm and vaginal cells with flow cytometry for DNA typing after sexual assault
journal, October 1999

Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel
journal, January 2004

Theory of long wavelength acoustic radiation pressure
journal, October 1991

Migration of suspended particles in plane stationary ultrasonic field
journal, January 1981

Increasing the luminescence of lanthanide complexes
journal, January 2006

Using acoustic radiation force as a concentration method for erythrocytes
journal, July 1997

Dynamics of suspended particles in a two-dimensional high-frequency sonic field
journal, June 1995

An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection
journal, January 2004

Single particle high resolution spectral analysis flow cytometry
journal, January 2006

Standing‐wave acoustic trap for nonintrusive positioning of microparticles
journal, October 1995

Acoustic separation in a laminar flow
conference, January 1994

Generalized rainbows and unfolded glories of oblate drops: organization for multiple internal reflections and extension of cusps into Alexander's dark band
journal, January 1994

Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels
journal, March 2005

Scanning flow cytometry for individual particle analysis
journal, January 2000

Evaluation of SDF-1/CXCR4-induced Ca²⁺ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry
journal, December 2002

Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width
journal, January 2003

Upper sound pressure limits on particle concentration in fields of ultrasonic standing-wave at megahertz frequencies
journal, January 1992

Cell–cell contact and membrane spreading in an ultrasound trap
journal, April 2004

Separation of dispersed phases from liquids in acoustically driven chambers
journal, February 1993

Acoustic concentration of particles in piezoelectric tubes: Theoretical modeling of the effect of cavity shape and symmetry breaking
journal, October 2004

Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid
journal, December 1994

On the drift of aerosol particles in sonic fields
journal, September 1992

Measurement of Mammalian Erythrocyte Indices from Light Scattering with Scaning Flow Cytometer
conference, January 2003

Data Analysis for a Dual-Channel Virus Counter
journal, April 2005

Manipulation of cells using an ultrasonic pressure field
journal, June 2005

Blue LED Excitable Temperature Sensors Based on a New Europium(III) Chelate
journal, February 2008

Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy
journal, January 1990

Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends
journal, July 2004

Spatial light-scattering analysis as a means of characterizing and classifying non-spherical particles
journal, February 1998

On the Possibility of Long-Wavelength Long-Lifetime High-Quantum-Yield Luminophores
journal, January 2001

Formation and growth of ice particles in stationary ultrasonic fields
journal, September 1998

The mean force acting on a small body in an axisymmetric sound field in a real medium
journal, January 1987

Plasma preparation from whole blood using ultrasound
journal, June 2000

Precise Measurements Of Particle Entrainment In A Standing-Wave Acoustic Field Between 20 And 3500 Hz
journal, December 2000

The effect of centreline particle concentration in a wave tube
journal, January 1996

Quantum mechanical representation of acoustic streaming and acoustic radiation pressure
journal, July 2001

Acoustic filtration and sedimentation of soot particles
journal, December 1997

A new immobilisation method to arrange particles in a gel matrix by ultrasound standing waves
journal, February 2005

Ultrasonic waves for fabricating lattice structure in composite materials
conference, September 1999

Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces
journal, January 2005

Acoustically aided separation of oil droplets from aqueous emulsions
journal, August 2004

Microparticle manipulation in millimetre scale ultrasonic standing wave chambers
journal, August 1998

Light-scattering properties of individual erythrocytes
journal, January 1999

Modelling of particle paths passing through an ultrasonic standing wave
journal, April 2004

Ultrasonic Micromanipulator Using Visual Feedback
journal, May 1996

Acoustic micromanipulation using a multi-electrode transducer
conference, January 1996

Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis
journal, March 2006

Progress in Lanthanides as Luminescent Probes
journal, July 2005

Single particle aerodynamic relaxation time analyzer
journal, June 1977

Enhanced synchronized ultrasonic and flow-field fractionation of suspensions
journal, March 1994

Batch and semicontinuous aggregation and sedimentation of hybridoma cells by acoustic resonance fields
journal, March 1995

The use of ultrasonic standing waves to enhance optical particle sizing equipment
journal, March 2000

Ultrasonic trapping of paramecia and estimation of their locomotive force
journal, October 1997

Design and characterization of a compact dual channel virus counter
journal, January 2005

Cellular platforms for HTS: three case studies
journal, March 2002

Resolving leukocytes using axial light loss
journal, July 1989

Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis
journal, March 2007

Ruthenium(II) complex with a notably long excited state lifetime
journal, January 2000

On the Acoustic Radiation Pressure on Spheres
journal, November 1934

Transport and harvesting of suspended particles using modulated ultrasound
journal, November 1991

Continuous Flow Microfluidic Device for Rapid Erythrocyte Lysis
journal, November 2004

A silicon microfluidic ultrasonic separator
journal, October 2003

Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results
journal, March 2002

Ultrasonic four‐wave mixing mediated by an aqueous suspension of microspheres: Theoretical steady‐state properties
journal, September 1995

Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels
journal, April 2005

Ultrasonic separations in analytical biotechnology
journal, December 1997

Concentration and Fractionation of Small Particles in Liquid by Ultrasound
journal, May 1995

Lanthanide-based luminescence probes and time-resolved luminescence bioassays
journal, May 2006

Extension of acoustic levitation to include the study of micron‐size particles in a more compressible host liquid
journal, May 1982

Separation of a biocatalyst with ultrafiltration or filtration after bioconversion
journal, March 1997

Experimental and theoretical study of light scattering by individual mature red blood cells by use of scanning flow cytometry and a discrete dipole approximation
journal, January 2005

Control of a Standing Wave Field Using a Line-Focused Transducer for Two-Dimensional Manipulation of Particles
journal, May 1998

Mean force on a small sphere in a sound field in a viscous fluid
journal, January 2000

Field-assisted extraction of cells, particles and macromolecules
journal, February 2002

Ultrasonic particle concentration in a line-driven cylindrical tube
journal, June 2005