Microgel particles for the delivery of bioactive materials
Abstract
Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.
- Inventors:
-
- Oakland, CA
- Atlanta, GA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1014464
- Patent Number(s):
- 7683041
- Application Number:
- U S Patent Application 11/388,924
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
- DOE Contract Number:
- AC03-76SF00098; AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Frechet, Jean M. J., and Niren, Murthy. Microgel particles for the delivery of bioactive materials. United States: N. p., 2010.
Web.
Frechet, Jean M. J., & Niren, Murthy. Microgel particles for the delivery of bioactive materials. United States.
Frechet, Jean M. J., and Niren, Murthy. Tue .
"Microgel particles for the delivery of bioactive materials". United States. https://www.osti.gov/servlets/purl/1014464.
@article{osti_1014464,
title = {Microgel particles for the delivery of bioactive materials},
author = {Frechet, Jean M. J. and Niren, Murthy},
abstractNote = {Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {3}
}
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