Selective high affinity polydentate ligands and methods of making such
Abstract
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
- Inventors:
-
- El Macero, CA
- Livermore, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); The Regents of California (Oakland, CA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1014201
- Patent Number(s):
- 7662785
- Application Number:
- US Patent Application 11/055,181
- Assignee:
- The Regents of California (Oakland, CA) ;Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Selective high affinity polydentate ligands and methods of making such. United States: N. p., 2010.
Web.
DeNardo, Sally, DeNardo, Gerald, & Balhorn, Rodney. Selective high affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Tue .
"Selective high affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1014201.
@article{osti_1014201,
title = {Selective high affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally and DeNardo, Gerald and Balhorn, Rodney},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {2}
}
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