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Title: Selective high affinity polydentate ligands and methods of making such

Abstract

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.

Inventors:
 [1];  [1];  [2]
  1. El Macero, CA
  2. Livermore, CA
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); The Regents of California (Oakland, CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1014201
Patent Number(s):
7662785
Application Number:
US Patent Application 11/055,181
Assignee:
The Regents of California (Oakland, CA) ;Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Selective high affinity polydentate ligands and methods of making such. United States: N. p., 2010. Web.
DeNardo, Sally, DeNardo, Gerald, & Balhorn, Rodney. Selective high affinity polydentate ligands and methods of making such. United States.
DeNardo, Sally, DeNardo, Gerald, and Balhorn, Rodney. Tue . "Selective high affinity polydentate ligands and methods of making such". United States. https://www.osti.gov/servlets/purl/1014201.
@article{osti_1014201,
title = {Selective high affinity polydentate ligands and methods of making such},
author = {DeNardo, Sally and DeNardo, Gerald and Balhorn, Rodney},
abstractNote = {This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {2}
}

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Works referenced in this record:

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