Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof
Abstract
The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.
- Inventors:
-
- Berkeley, CA
- Albany, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1014177
- Patent Number(s):
- 7666850
- Application Number:
- US Patent Application 11/150,406
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Bissell, Mina J, and Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States: N. p., 2010.
Web.
Bissell, Mina J, & Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States.
Bissell, Mina J, and Muschler, John L. Tue .
"Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof". United States. https://www.osti.gov/servlets/purl/1014177.
@article{osti_1014177,
title = {Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof},
author = {Bissell, Mina J and Muschler, John L},
abstractNote = {The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {2}
}
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