The Scripps Research Institute (La Jolla, CA)
Abstract
The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.
- Inventors:
-
- La Jolla, CA
- San Diego, CA
- Issue Date:
- Research Org.:
- The Scripps Research Inst., La Jolla, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1014081
- Patent Number(s):
- 7642085
- Application Number:
- US Patent Application 10/744,899
- Assignee:
- The Scripps Research Institute (La Jolla, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- FG03-00ER45812
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Schultz, Peter G, and Wang, Lei. The Scripps Research Institute (La Jolla, CA). United States: N. p., 2010.
Web.
Schultz, Peter G, & Wang, Lei. The Scripps Research Institute (La Jolla, CA). United States.
Schultz, Peter G, and Wang, Lei. Tue .
"The Scripps Research Institute (La Jolla, CA)". United States. https://www.osti.gov/servlets/purl/1014081.
@article{osti_1014081,
title = {The Scripps Research Institute (La Jolla, CA)},
author = {Schultz, Peter G and Wang, Lei},
abstractNote = {The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the protein, which unnatural amino acid includes a reactive group that can react with a second reactive group that is attached to a solid support.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {1}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface.
journal, November 1993
- Francisco, J. A.; Campbell, R.; Iverson, B. L.
- Proceedings of the National Academy of Sciences, Vol. 90, Issue 22
Progress toward the evolution of an organism with an expanded genetic code
journal, April 1999
- Liu, David R.; Schultz, Peter G.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 9, p. 4780-4785
By-passing selection: direct screening for antibody-antigen interactions using protein arrays
journal, August 2000
- Holt, L. J.
- Nucleic Acids Research, Vol. 28, Issue 15
Unprotected Peptides as Building Blocks for the Synthesis of Peptide Dendrimers with Oxime, Hydrazone, and Thiazolidine Linkages
journal, April 1995
- Shao, Jun; Tam, James P.
- Journal of the American Chemical Society, Vol. 117, Issue 14, p. 3893-3899
Solid Phase Assembly of Defined Protein Conjugates
journal, September 2002
- Russell, John C.; Colpitts, Tracey L.; Holets-McCormack, Shelley R.
- Bioconjugate Chemistry, Vol. 13, Issue 5
Biosensor chip mass spectrometry: A chip-based proteomics approach
journal, April 2000
- Nelson, Randall W.; Nedelkov, Dobrin; Tubbs, Kemmons A.
- Electrophoresis, Vol. 21, Issue 6, p. 1155-1163
UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions
journal, January 2000
- Ge, H.
- Nucleic Acids Research, Vol. 28, Issue 2
Efficient introduction of aryl bromide functionality into proteins in vivo
journal, February 2000
- Sharma, Nandita; Furter, Rolf; Kast, Peter
- FEBS Letters, Vol. 467, Issue 1, p. 37-40
Recent developments and applications of liquid-phase strategies in organic synthesis
journal, November 1999
- Wentworth, Paul
- Trends in Biotechnology, Vol. 17, Issue 11
Yeast forward and reverse 'n'-hybrid systems
journal, February 1999
- Vidal, M.
- Nucleic Acids Research, Vol. 27, Issue 4
Metallopeptide Design: Tuning the Metal Cation Affinities with Unnatural Amino Acids and Peptide Secondary Structure
journal, January 1996
- Cheng, Richard P.; Fisher, Stewart L.; Imperiali, Barbara
- Journal of the American Chemical Society, Vol. 118, Issue 46
Site-Specific Protein Modification Using a Ketone Handle
journal, January 1996
- Cornish, Virginia W.; Hahn, Klaus M.; Schultz, Peter G.
- Journal of the American Chemical Society, Vol. 118, Issue 34, p. 8150-8151
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
journal, February 2000
- Uetz, Peter; Giot, Loic; Cagney, Gerard
- Nature, Vol. 403, Issue 6770
Addition of the keto functional group to the genetic code of Escherichia coli
journal, December 2002
- Wang, L.; Zhang, Z.; Brock, A.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 1, p. 56-61
A Novel Hydrazine Linker Resin and Its Application for the Solid-Phase Synthesis of α-Branched Primary Amines
journal, January 2001
- Kirchhoff, Jan H.; Bräse, Stefan; Enders, Dieter
- Journal of Combinatorial Chemistry, Vol. 3, Issue 1
A New Strategy for the Site-Specific Modification of Proteins in Vivo
journal, June 2003
- Zhang, Zhiwen; Smith, Brian A. C.; Wang, Lei
- Biochemistry, Vol. 42, Issue 22, p. 6735-6746
Expanding the Genetic Code of Escherichia coli
journal, April 2001
- Wang, L.; Brock, A.; Herberich, B.
- Science, Vol. 292, Issue 5516, p. 498-500