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Title: Materials and methods for efficient lactic acid production

Abstract

The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.

Inventors:
 [1];  [2];  [2];  [2];  [2];  [2]
+ Show Inventor Affiliations
  1. Sycamore, IL
  2. Gainesville, FL
Issue Date:
Research Org.:
University of Florida Research Foundation, Inc. (Gainesville, FL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1013854
Patent Number(s):
7629162
Application Number:
US Patent Application 11/501,137
Assignee:
University of Florida Research Foundation, Inc. (Gainesville, FL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
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DOE Contract Number:  
FG02-96ER20222
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Zhou, Shengde, Ingram, Lonnie O'Neal, Shanmugam, Keelnatham T, Yomano, Lorraine, Grabar, Tammy B, and Moore, Jonathan C. Materials and methods for efficient lactic acid production. United States: N. p., 2009. Web.
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Zhou, Shengde, Ingram, Lonnie O'Neal, Shanmugam, Keelnatham T, Yomano, Lorraine, Grabar, Tammy B, & Moore, Jonathan C. Materials and methods for efficient lactic acid production. United States.
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Zhou, Shengde, Ingram, Lonnie O'Neal, Shanmugam, Keelnatham T, Yomano, Lorraine, Grabar, Tammy B, and Moore, Jonathan C. Tue . "Materials and methods for efficient lactic acid production". United States. https://www.osti.gov/servlets/purl/1013854.
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@article{osti_1013854,
title = {Materials and methods for efficient lactic acid production},
author = {Zhou, Shengde and Ingram, Lonnie O'Neal and Shanmugam, Keelnatham T and Yomano, Lorraine and Grabar, Tammy B and Moore, Jonathan C},
abstractNote = {The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 08 00:00:00 EST 2009},
month = {Tue Dec 08 00:00:00 EST 2009}
}
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Works referenced in this record:

From famine to feast: the role of methylglyoxal production in Escherichia coli
journal, February 1998

Fermentation of 12% (w/v) Glucose to 1.2 m Lactate by Escherichia coli Strain SZ194 using Mineral Salts Medium
journal, May 2006

Fermentation of 10% (w/v) Sugar to D(−)-Lactate by Engineered Escherichia coli B
journal, December 2005

Production of Optically Pure D-Lactic Acid in Mineral Salts Medium by Metabolically Engineered Escherichia coli W3110
journal, January 2003

Recombinant Escherichia coli engineered for production of L-lactic acid from hexose and pentose sugars
journal, October 2001

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