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Title: Direct imaging of neural currents using ultra-low field magnetic resonance techniques

Abstract

Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.

Inventors:
 [1];  [1];  [1];  [1];  [2]
  1. Los Alamos, NM
  2. (Los Alamos, NM)
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1013688
Patent Number(s):
7573268
Application Number:
11/678,023
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, and Kraus, Jr., Robert H.. Direct imaging of neural currents using ultra-low field magnetic resonance techniques. United States: N. p., 2009. Web.
Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, & Kraus, Jr., Robert H.. Direct imaging of neural currents using ultra-low field magnetic resonance techniques. United States.
Volegov, Petr L, Matlashov, Andrei N, Mosher, John C, Espy, Michelle A, and Kraus, Jr., Robert H.. Tue . "Direct imaging of neural currents using ultra-low field magnetic resonance techniques". United States. https://www.osti.gov/servlets/purl/1013688.
@article{osti_1013688,
title = {Direct imaging of neural currents using ultra-low field magnetic resonance techniques},
author = {Volegov, Petr L and Matlashov, Andrei N and Mosher, John C and Espy, Michelle A and Kraus, Jr., Robert H.},
abstractNote = {Using resonant interactions to directly and tomographically image neural activity in the human brain using magnetic resonance imaging (MRI) techniques at ultra-low field (ULF), the present inventors have established an approach that is sensitive to magnetic field distributions local to the spin population in cortex at the Larmor frequency of the measurement field. Because the Larmor frequency can be readily manipulated (through varying B.sub.m), one can also envision using ULF-DNI to image the frequency distribution of the local fields in cortex. Such information, taken together with simultaneous acquisition of MEG and ULF-NMR signals, enables non-invasive exploration of the correlation between local fields induced by neural activity in cortex and more `distant` measures of brain activity such as MEG and EEG.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {8}
}

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Works referenced in this record:

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging
journal, August 2003


SQUID detected NMR in microtesla magnetic fields
journal, September 2004


SQUID-Based Simultaneous Detection of NMR and Biomagnetic Signals at Ultra-Low Magnetic Fields
journal, June 2005