Apparatus for detecting and recognizing analytes based on their crystallization patterns
Abstract
The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.
- Inventors:
-
- Manassas, VA
- Cross Junction, VA
- Kensington, MD
- Issue Date:
- Research Org.:
- George Mason Intellectual Properties, Inc. (Fairfax, VA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1011387
- Patent Number(s):
- 7850915
- Application Number:
- 12/041,295
- Assignee:
- George Mason Intellectual Properties, Inc. (Fairfax, VA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C30 - CRYSTAL GROWTH C30B - SINGLE-CRYSTAL-GROWTH
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- DOE Contract Number:
- FC52-04NA25455
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Apparatus for detecting and recognizing analytes based on their crystallization patterns. United States: N. p., 2010.
Web.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, & Elliott, Adam. Apparatus for detecting and recognizing analytes based on their crystallization patterns. United States.
Morozov, Victor, Bailey, Charles L, Vsevolodov, Nikolai N, and Elliott, Adam. Tue .
"Apparatus for detecting and recognizing analytes based on their crystallization patterns". United States. https://www.osti.gov/servlets/purl/1011387.
@article{osti_1011387,
title = {Apparatus for detecting and recognizing analytes based on their crystallization patterns},
author = {Morozov, Victor and Bailey, Charles L and Vsevolodov, Nikolai N and Elliott, Adam},
abstractNote = {The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}
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Works referenced in this record:
Urinary crystal surface binding substances on calcium oxalate crystals
journal, December 1990
- Koide, T.; Yoshioka, T.; Yamaguchi, S.
- Urological Research, Vol. 18, Issue 6