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Title: Apparatus for detecting and recognizing analytes based on their crystallization patterns

Abstract

The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.

Inventors:
 [1];  [2];  [3];  [1]
  1. (Manassas, VA)
  2. (Cross Junction, VA)
  3. (Kensington, MD)
Issue Date:
Research Org.:
George Mason Intellectual Properties, Inc. (Fairfax, VA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1011387
Patent Number(s):
7,850,915
Application Number:
12/041,295
Assignee:
George Mason Intellectual Properties, Inc. (Fairfax, VA) NNSASC
DOE Contract Number:  
FC52-04NA25455
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Morozov, Victor, Bailey, Charles L., Vsevolodov, Nikolai N., and Elliott, Adam. Apparatus for detecting and recognizing analytes based on their crystallization patterns. United States: N. p., 2010. Web.
Morozov, Victor, Bailey, Charles L., Vsevolodov, Nikolai N., & Elliott, Adam. Apparatus for detecting and recognizing analytes based on their crystallization patterns. United States.
Morozov, Victor, Bailey, Charles L., Vsevolodov, Nikolai N., and Elliott, Adam. Tue . "Apparatus for detecting and recognizing analytes based on their crystallization patterns". United States. https://www.osti.gov/servlets/purl/1011387.
@article{osti_1011387,
title = {Apparatus for detecting and recognizing analytes based on their crystallization patterns},
author = {Morozov, Victor and Bailey, Charles L. and Vsevolodov, Nikolai N. and Elliott, Adam},
abstractNote = {The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

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