Title: Protection of the female reproductive system from natural and artificial insults

Abstract

Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.

Inventors:

Tilly, Jonathan L ^[1]; Kolesnick, Richard N ^[2]

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+ Show Inventor Affiliations

1. Windham, NH
2. New York, NY

Issue Date:

2010-12-14

Research Org.:

The General Hospital Corporation (Boston, MA); Memorial Sloan-Kettering Cancer Center (New York, NY)

Sponsoring Org.:

USDOE

OSTI Identifier:

1011386

Patent Number(s):

7850984

Application Number:

10/217,259

Assignee:

The General Hospital Corporation (Boston, MA); Memorial Sloan-Kettering Cancer Center (New York, NY)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/66 - Phosphorus compounds
A61K31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
A61K31/685 - one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K31/688 - both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P15/08 - for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

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Resource Type:

Patent

Country of Publication:

United States

Language:

English