skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Functionalized apertures for the detection of chemical and biological materials

Abstract

Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.

Inventors:
 [1];  [1];  [2];  [2];  [3];  [3]
  1. (Livermore, CA)
  2. (Danville, CA)
  3. (Brentwood, CA)
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1010280
Patent Number(s):
7,851,203
Application Number:
10/677,395
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) OAK
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Letant, Sonia E., van Buuren, Anthony W., Terminello, Louis J., Thelen, Michael P., Hope-Weeks, Louisa J., and Hart, Bradley R. Functionalized apertures for the detection of chemical and biological materials. United States: N. p., 2010. Web.
Letant, Sonia E., van Buuren, Anthony W., Terminello, Louis J., Thelen, Michael P., Hope-Weeks, Louisa J., & Hart, Bradley R. Functionalized apertures for the detection of chemical and biological materials. United States.
Letant, Sonia E., van Buuren, Anthony W., Terminello, Louis J., Thelen, Michael P., Hope-Weeks, Louisa J., and Hart, Bradley R. Tue . "Functionalized apertures for the detection of chemical and biological materials". United States. https://www.osti.gov/servlets/purl/1010280.
@article{osti_1010280,
title = {Functionalized apertures for the detection of chemical and biological materials},
author = {Letant, Sonia E. and van Buuren, Anthony W. and Terminello, Louis J. and Thelen, Michael P. and Hope-Weeks, Louisa J. and Hart, Bradley R.},
abstractNote = {Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

Patent:

Save / Share: