Closure for milliliter scale bioreactor
Abstract
A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.
- Inventors:
-
- Palo Alto, CA
- Albany, CA
- Moss Beach, CA
- Issue Date:
- Research Org.:
- Gener 8 Inc
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1010278
- Patent Number(s):
- 7851204
- Application Number:
- 11/450,855
- Assignee:
- Pall Microreactor Technologies, Inc. (Mountain View, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
- DOE Contract Number:
- FG02-04ER83963
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Klein, David L, Laidlaw, Robert D, Andronaco, Gregory, and Boyer, Stephen G. Closure for milliliter scale bioreactor. United States: N. p., 2010.
Web.
Klein, David L, Laidlaw, Robert D, Andronaco, Gregory, & Boyer, Stephen G. Closure for milliliter scale bioreactor. United States.
Klein, David L, Laidlaw, Robert D, Andronaco, Gregory, and Boyer, Stephen G. Tue .
"Closure for milliliter scale bioreactor". United States. https://www.osti.gov/servlets/purl/1010278.
@article{osti_1010278,
title = {Closure for milliliter scale bioreactor},
author = {Klein, David L and Laidlaw, Robert D and Andronaco, Gregory and Boyer, Stephen G},
abstractNote = {A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
A microfabricated electrochemical oxygen generator for high-density cell culture arrays
journal, October 2003
- Maharbiz, M. M.; Holtz, W. J.; Sharifzadeh, S.
- Journal of Microelectromechanical Systems, Vol. 12, Issue 5
Monitoring of Cell Growth, Oxygen and pH in Microfermentors
book, January 2002
- Szita, Nicolas; Zanzotto, Andrea; Boccazzi, Paolo
- Micro Total Analysis Systems 2002
Luminescence Lifetime Imaging of Oxygen, pH, and Carbon Dioxide Distribution Using Optical Sensors
journal, April 2000
- Liebsch, Gregor; Klimant, Ingo; Frank, Bernhard
- Applied Spectroscopy, Vol. 54, Issue 4
Potential applications of lifetime-based, phase-modulation fluorimetry in bioprocess and clinical monitoring
journal, March 1995
- Bambot, Shabbir B.; Lakowicz, Joseph R.; Rao, Govind
- Trends in Biotechnology, Vol. 13, Issue 3
Microbioreactor arrays with parametric control for high-throughput experimentation
journal, January 2004
- Maharbiz, Michel M.; Holtz, William J.; Howe, Roger T.
- Biotechnology and Bioengineering, Vol. 85, Issue 4