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Title: Method for detecting binding events using micro-X-ray fluorescence spectrometry

Abstract

Method for detecting binding events using micro-X-ray fluorescence spectrometry. Receptors are exposed to at least one potential binder and arrayed on a substrate support. Each member of the array is exposed to X-ray radiation. The magnitude of a detectable X-ray fluorescence signal for at least one element can be used to determine whether a binding event between a binder and a receptor has occurred, and can provide information related to the extent of binding between the binder and receptor.

Inventors:
 [1];  [1];  [2]
  1. Los Alamos, NM
  2. Hong Kong, HK
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1009131
Patent Number(s):
7858385
Application Number:
09/859,701
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Warner, Benjamin P, Havrilla, George J, and Mann, Grace. Method for detecting binding events using micro-X-ray fluorescence spectrometry. United States: N. p., 2010. Web.
Warner, Benjamin P, Havrilla, George J, & Mann, Grace. Method for detecting binding events using micro-X-ray fluorescence spectrometry. United States.
Warner, Benjamin P, Havrilla, George J, and Mann, Grace. Tue . "Method for detecting binding events using micro-X-ray fluorescence spectrometry". United States. https://www.osti.gov/servlets/purl/1009131.
@article{osti_1009131,
title = {Method for detecting binding events using micro-X-ray fluorescence spectrometry},
author = {Warner, Benjamin P and Havrilla, George J and Mann, Grace},
abstractNote = {Method for detecting binding events using micro-X-ray fluorescence spectrometry. Receptors are exposed to at least one potential binder and arrayed on a substrate support. Each member of the array is exposed to X-ray radiation. The magnitude of a detectable X-ray fluorescence signal for at least one element can be used to determine whether a binding event between a binder and a receptor has occurred, and can provide information related to the extent of binding between the binder and receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

Works referenced in this record:

Quantitation of antibody binding to cell surface antigens by X-ray fluorescence spectrometry
journal, March 1979


Determination of ruthenium on DNA by XRF
journal, August 1987


Qualitative Analysis of Solid Phase Synthesis Reaction Products by X-ray Spectrometry
journal, November 1997


X-Ray Fluorescence Analysis Applied to Small Samples
journal, January 1977


Synchrotron x-ray microbeam diagnostics of combinatorial synthesis
journal, September 1998