Dual chain synthetic heparin-binding growth factor analogs
Abstract
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
- Inventors:
-
- Gaithersburg, MD
- Poquott, NY
- Plainview, NY
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1001993
- Patent Number(s):
- 7598224
- Application Number:
- 11/065,970
- Assignee:
- BioSurface Engineering Technologies, Inc. (Rockville, MD)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Zamora, Paul O, Pena, Louis A, and Lin, Xinhua. Dual chain synthetic heparin-binding growth factor analogs. United States: N. p., 2009.
Web.
Zamora, Paul O, Pena, Louis A, & Lin, Xinhua. Dual chain synthetic heparin-binding growth factor analogs. United States.
Zamora, Paul O, Pena, Louis A, and Lin, Xinhua. Tue .
"Dual chain synthetic heparin-binding growth factor analogs". United States. https://www.osti.gov/servlets/purl/1001993.
@article{osti_1001993,
title = {Dual chain synthetic heparin-binding growth factor analogs},
author = {Zamora, Paul O and Pena, Louis A and Lin, Xinhua},
abstractNote = {The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {10}
}
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