%0Computer Program %TGriffin: A Moose-based Reactor Multiphysics Application For Radiation Transport And Depletion Simulations %XGriffin is a MOOSE-based reactor multiphysics application that streamlines the analysis of a variety of nuclear multiphysics applications, including steady-state and transient radiation transport, core performance, fuel depletion, criticality and decay heat calculations, reprocessing and post-irradiation examination. This streamlining is accomplished via enhanced flexibility of the tools, uniform syntax in the MOOSE framework, dynamic linking of all relevant physics and a single point of execution. The design for flexible multi-physics, multi-radiation, multi-scheme tasks demands and ultimately makes Griffin a highly extendable code system. A software quality assurance (SQA) procedure is enforced during Griffin development. %ADeHart, Mark %AOrtensi, Javier %AWang, Yai %ALaboure, Vincent %APrince, Zachary %AHarter, Jackson %ASchunert, Sebastian %ACalvin, Olin %ALee, Changho %AShemon, Emily %AJung, Yeon %Rhttps://doi.org/ %Uhttps://www.osti.gov/doecode/biblio/120444 %CUnited States %D2021 %GEnglish %2USDOE Office of Nuclear Energy (NE) %1AC07-05ID14517 2021-05-05