Omics-Lethal Human Viruses, West Nile Experiment WLN003

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVWLN003/1661961

Title: Omics-Lethal Human Viruses, West Nile Experiment WLN003

Abstract

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse popliteal draining lymph nodes for proteomics, metabolomics, and lipidomics expression analysis. See Experiment WLN002 for corresponding transcriptome analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: Mon Jan 18 00:00:00 EST 2021

Other Number(s):: WLN003
MassIVE: MSV000080354 (lipidome);MassIVE: MSV000080021 (metabolome);MassIVE: MSV000080024 (proteome)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Human virus [NCIT:C14317]; Middle East respiratory syndrome-related coronavirus [NCBITAXON:1335626]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]

OSTI Identifier:: 1661961

DOI:: https://doi.org/10.25584/LHVWLN003/1661961

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WLN003.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVWLN003/1661961.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WLN003.  United States.  doi:https://doi.org/10.25584/LHVWLN003/1661961

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, West Nile Experiment WLN003".  United States.  doi:https://doi.org/10.25584/LHVWLN003/1661961.  https://www.osti.gov/servlets/purl/1661961. Pub date:Mon Jan 18 00:00:00 EST 2021

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@article{osti_1661961,

  title        = {Omics-Lethal Human Viruses, West Nile Experiment WLN003},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse popliteal draining lymph nodes for proteomics, metabolomics, and lipidomics expression analysis. See Experiment WLN002 for corresponding transcriptome analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics, metabolomics, and lipidomics dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.},

  doi          = {10.25584/LHVWLN003/1661961},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 18 00:00:00 EST 2021},

  month        = {Mon Jan 18 00:00:00 EST 2021}

}

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DOI: https://doi.org/10.25584/LHVWLN003/1661961

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Works referenced in this record:

Wln002
dataset, January 2020

Waters, Katrina; Anderson, Lindsey; McDermott, Jason
Pacific Northwest National Laboratory 2; EMSL; PNNL
https://doi.org/10.25584/LHVWLN002/1661960

Works referencing / citing this record:

PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVWNV/1784305

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The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells for mRNA and proteomics expression analysis. See Experiment WDC011 (GSE75222) for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics and transcriptomics, each dataset download has a direct relationship to a primary sample submission corresponding to amore » specific West Nile virus infection.« less

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Title: Omics-Lethal Human Viruses, West Nile Experiment WLN003

Abstract

Citation Formats

Wln002 dataset, January 2020

PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs dataset, January 2021

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PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs
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