Omics-Lethal Human Viruses, West Nile Experiment WLN002

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVWLN002/1661960

Title: Omics-Lethal Human Viruses, West Nile Experiment WLN002

Dataset
Other Related Research

Abstract

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse popliteal draining lymph nodes for mRNA and miRNA expression analysis. See Experiment WLN003 for corresponding omics analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Pacific Northwest National Laboratory, Biological Sciences Division
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Publication Date:: 2021-01-17

Other Number(s):: WLN002
NCBI BioProject: PRJNA314302 (mRNA); NCBI BioProject: PRJNA314303 (miRNA); GEO Series: GSE78888 (mRNA); GEO Series: GSE78887 (miRNA)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES; BioProject Accession Number [NCIT:C175890]; Data Download [schema:DataDownload]; Gene expression profile data [edam.data:0928]; Immune Response [GO:0006955]; Mus musculus [NCBITAXON:10090]; Omics [edam.topic:3391]; Time Sampled Measurement Datasets [IAO:0000584]; Virology [edam.topic:0781]; West Nile Virus [NCBITAXON:11082]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]

OSTI Identifier:: 1661960

DOI:: https://doi.org/10.25584/LHVWLN002/1661960

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WLN002.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVWLN002/1661960.

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WLN002.  United States.  doi:https://doi.org/10.25584/LHVWLN002/1661960

Copy to clipboard


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, West Nile Experiment WLN002".  United States.  doi:https://doi.org/10.25584/LHVWLN002/1661960.  https://www.osti.gov/servlets/purl/1661960. Pub date:Sun Jan 17 23:00:00 EST 2021

Copy to clipboard


                    
@article{osti_1661960,

  title        = {Omics-Lethal Human Viruses, West Nile Experiment WLN002},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse popliteal draining lymph nodes for mRNA and miRNA expression analysis. See Experiment WLN003 for corresponding omics analysis. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.},

  doi          = {10.25584/LHVWLN002/1661960},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {2021},

  month        = {1}

}

Copy to clipboard

Dataset:

View Dataset

DOI: https://doi.org/10.25584/LHVWLN002/1661960

Save / Share:

Export Metadata

Save to My Library

Similar records in DOE Data Explorer and OSTI.GOV collections:

Omics-Lethal Human Viruses, West Nile Experiment WCB001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant WNV-E218A virus infection. Sample data was obtained from mouse cerebellum tissue and processed for mRNA, miRNA, proteomics, metabolomics, and lipidomics expression analysis. Tissues from this experiment were matched to tissues from GSE77193 (WCT001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities formore »« less
Omics-Lethal Human Viruses, West Nile Experiment WCN002

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse cortical neuron tissue and processed for mRNA and miRNA expression analysis. This data set comprises two complete biological replicate experiments conducted in the same conditions and with data processed independently (WCN003). Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primarymore »« less
Omics-Lethal Human Viruses, West Nile Experiment WCN003

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained frommouse cortical neuron tissue for mRNA and miRNA expression analysis. Biological replicate experiments were conducted in the same conditions and with data processed independently (WCN002). Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific West Nilemore » virus infection.« less
Omics-Lethal Human Viruses, West Nile Experiment WCT001

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data was obtained from mouse cortex tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics expression analysis. Tissues from this experiment were matched to tissues from GSE77192 (WCB001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolutionmore »« less
Omics-Lethal Human Viruses, West Nile Experiment WDC010

Dataset Anderson, Lindsey N. ; Eisfeld, Amie J. ; Waters, Katrina M.

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells for mRNA and proteomics expression analysis. See Experiment WDC011 (GSE75222) for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics and transcriptomics, each dataset download has a direct relationship to a primary sample submission corresponding to amore » specific West Nile virus infection.« less

Similar Records