Omics-Lethal Human Viruses, West Nile Experiment WDC010

Anderson, Lindsey N.; Eisfeld, Amie J.; Waters, Katrina M.

doi:10.25584/LHVWDC010/1661955

Title: Omics-Lethal Human Viruses, West Nile Experiment WDC010

Abstract

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells for mRNA and proteomics expression analysis. See Experiment WDC011 (GSE75222) for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics and transcriptomics, each dataset download has a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

Authors:

;

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Publication Date:: 2021-01-18

Other Number(s):: WDC010
NCBI BioProject: PRJNA301036;GEO Series: GSE74628 (mRNA);MassIVE: MSV000079470 (proteome)

DOE Contract Number:: AC05-76RL01830

Research Org.:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)

Collaborations:: Modeling Host Responses to Understand Severe Human Virus Infections Program Project

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Keywords:: Virology [edam.topic:0781]; Immune Response [GO:0006955]; Mus musculus [NCBITAXON:10090]; West Nile Virus [NCBITAXON:11082]; Time Sampled Measurement Datasets [IAO:0000584]; Mass spectrometry data [edam.data:2536]; MassIVE dataset identifier [MS:1002487]; Gene expression profile data [edam.data:0928]; BioProject Accession Number [NCIT:C175890]; Omics [edam.topic:3391]; Multi-omics [edam.topic:4021]; data transformation [SIO:000594]; differential expression analysis [SWO:7000018]; Data Download [schema:DataDownload]

OSTI Identifier:: 1661955

DOI:: https://doi.org/10.25584/LHVWDC010/1661955

Citation Formats


                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WDC010.  United States: N. p., 2021. 
        Web.  doi:10.25584/LHVWDC010/1661955.

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                    Anderson, Lindsey N., Eisfeld, Amie J., & Waters, Katrina M. Omics-Lethal Human Viruses, West Nile Experiment WDC010.  United States.  doi:https://doi.org/10.25584/LHVWDC010/1661955

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                    Anderson, Lindsey N., Eisfeld, Amie J., and Waters, Katrina M. 2021.  
"Omics-Lethal Human Viruses, West Nile Experiment WDC010".  United States.  doi:https://doi.org/10.25584/LHVWDC010/1661955.  https://www.osti.gov/servlets/purl/1661955. Pub date:Mon Jan 18 00:00:00 EST 2021

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@article{osti_1661955,

  title        = {Omics-Lethal Human Viruses, West Nile Experiment WDC010},

  author       = {Anderson, Lindsey N. and Eisfeld, Amie J. and Waters, Katrina M.},

  abstractNote = {The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells for mRNA and proteomics expression analysis. See Experiment WDC011 (GSE75222) for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics and transcriptomics, each dataset download has a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.},

  doi          = {10.25584/LHVWDC010/1661955},

  journal      = {},

  number       = ,

  volume       = ,

  place        = {United States},

  year         = {2021},

  month        = {1}

}

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DOI: https://doi.org/10.25584/LHVWDC010/1661955

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Works referenced in this record:

Wdc011
dataset, January 2020

Waters, Katrina; Anderson, Lindsey; McDermott, Jason
Pacific Northwest National Laboratory 2; EMSL; PNNL
https://doi.org/10.25584/LHVWDC011/1661956

Works referencing / citing this record:

PNNL DataHub Omics Lethal Human Viruses Project, Modeling Host Responses to West Nile Infection Post-Processed Data Package DOIs
dataset, January 2021

Anderson, Lindsey; McDermott, Jason; Waters, Katrina
Pacific Northwest National Laboratory 2; PNNL
https://doi.org/10.25584/LHVWNV/1784305

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The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells for mRNA expression analysis. See Experiment WDC010 (GSE74628) for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

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